NOS1-IN-1
Based on 1 Customer Validation
NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP).
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 357965-99-2
- Formula: C14H24F9N7O8
- Molecular Weight:589.37
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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nNOS 120 nM (Ki) |
Chemical Information
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CAS No. 357965-99-2
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Appearance Solid
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Molecular Weight 589.37
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Formula C14H24F9N7O8
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Color White to off-white
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SMILES
N=C(N[N+]([O-])=O)NCCC[C@H](N)CNCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : ≥ 50 mg/mL (84.84 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. J M Hah, et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44(16):2667-70. [Content Brief]
[2]. Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65(2):209-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6967 mL | 8.4836 mL | 16.9673 mL | 42.4182 mL |
| 5 mM | 0.3393 mL | 1.6967 mL | 3.3935 mL | 8.4836 mL | |
| 10 mM | 0.1697 mL | 0.8484 mL | 1.6967 mL | 4.2418 mL | |
| 15 mM | 0.1131 mL | 0.5656 mL | 1.1312 mL | 2.8279 mL | |
| 20 mM | 0.0848 mL | 0.4242 mL | 0.8484 mL | 2.1209 mL | |
| 25 mM | 0.0679 mL | 0.3393 mL | 0.6787 mL | 1.6967 mL | |
| 30 mM | 0.0566 mL | 0.2828 mL | 0.5656 mL | 1.4139 mL | |
| 40 mM | 0.0424 mL | 0.2121 mL | 0.4242 mL | 1.0605 mL | |
| 50 mM | 0.0339 mL | 0.1697 mL | 0.3393 mL | 0.8484 mL | |
| 60 mM | 0.0283 mL | 0.1414 mL | 0.2828 mL | 0.7070 mL | |
| 80 mM | 0.0212 mL | 0.1060 mL | 0.2121 mL | 0.5302 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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