Ochratoxin B¹³C₂₀ 

Ochratoxin B-¹³C₂₀ is ¹³C-labeled Ochratoxin B (HY-N6786). Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos^{[1][2][3][4][5][6][7]}.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

389.22

¹³C₂₀H₁₉NO₆

4825-86-9

O=[13C]1O[13C@@H]([13CH3])[13CH2][13C]2=[13C]1[13C](O)=[13C]([13C](N[13C@H]([13C](O)=O)[13CH2][13C]3=[13CH][13CH]=[13CH][13CH]=[13CH]3)=O)[13CH]=[13CH]2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220.  [Content Brief]

  [2]. Knasmüller S, et al. Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: implications for risk assessment. Nutr Cancer. 2004;50(2):190-7.  [Content Brief]

  [3]. O'Brien E, et al. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system. Birth Defects Res B Dev Reprod Toxicol. 2005 Oct;74(5):417-23.  [Content Brief]

  [4]. Dietrich DR, et al. Species- and sex-specific renal cytotoxicity of ochratoxin A and B in vitro. Exp Toxicol Pathol. 2001 Jun;53(2-3):215-25.  [Content Brief]

  [5]. Csenki Z, et al. The individual and combined effects of ochratoxin A with citrinin and their metabolites (ochratoxin B, ochratoxin C, and dihydrocitrinone) on 2D/3D cell cultures, and zebrafish embryo models. Food Chem Toxicol. 2021 Dec;158:112674.  [Content Brief]

  [6]. Mally A, et al. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicol Appl Pharmacol. 2005 Aug 1;206(1):43-53.  [Content Brief]

  [7]. Størmer FC, et al. Metabolism of ochratoxin B and its possible effects upon the metabolism and toxicity of ochratoxin A in rats. Appl Environ Microbiol. 1985 May;49(5):1108-12.  [Content Brief]