2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Ochratoxin B

Ochratoxin B  (Synonyms: オクラトキシンB)

製品番号: HY-N6786 純度: 99.90%
COA 取扱説明書 Technical Support

Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos.

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Ochratoxin B

Ochratoxin B 構造式

CAS 番号 : 4825-86-9

容量 価格（税別） 在庫状況 数量
1 mg $190 在庫あり
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10 mg   お問い合わせ  

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Ochratoxin B 関連抗体

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製品説明

Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos[1][2][3][4][5][6].

IC50 & Target

Microbial Metabolite

 

体外実験

Ochratoxin B (1-25 µg/mL) causes pronounced inhibition of HepG2 cell division[1].
Ochratoxin B (96 h) causes craniofacial malformations in Xenopus laevis embryos with less potency than Ochratoxin A[2].
Ochratoxin B (0.001-100 mM; 24-96 h) shows different cytotoxicity levels in primary porcine (PKC), rat (RPTC), human renal proximal epithelial cells (HKC) and porcine renal cell line (LLC-PK1)[3].
Ochratoxin B (2.5-25 μM) at lower concentrations (2.5 and 5 μM) reduces, and at higher subtoxic concentrations (25 μM) increases, Ochratoxin A-mediated toxicity in 3D MDCK cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ochratoxin B 関連抗体
体内実験

Ochratoxin B (single dose of 10 mg/kg bw or repeated doses of 2 mg/kg bw; p.o.; single dose or 5 days/week, 2 weeks) shows no significant adverse effects in rats[5].
Ochratoxin B (4 mg/kg; i.p.) considerably reduces the toxic effects of Ochratoxin A when given together with Ochratoxin A in rats[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male F344 Fisher rats (8-9 weeks old, 150-170 g)[5]
Dosage: Single dose of 10 mg/kg bw or repeated doses of 2 mg/kg bw (in corn oil)
Administration: Oral gavage, single dose or 5 days/week, 2 weeks
Result: Showed a slight increase in mitotic figures in proximal tubule cells (a single high dose).
Showed no changes in clinical chemistry, renal function, and histopathology (repeated administration).
Was more extensively metabolized and more rapidly eliminated than Ochratoxin A.
分子量

369.37

分子式

C20H19NO6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1O[C@H](CC2=C1C(O)=C(C=C2)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)C
Structure Classification
Initial Source

Aspergillus ochraceus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 15 mg/mL (40.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7073 mL 13.5366 mL 27.0731 mL
5 mM 0.5415 mL 2.7073 mL 5.4146 mL
10 mM 0.2707 mL 1.3537 mL 2.7073 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7073 mL 13.5366 mL 27.0731 mL 67.6828 mL
5 mM 0.5415 mL 2.7073 mL 5.4146 mL 13.5366 mL
10 mM 0.2707 mL 1.3537 mL 2.7073 mL 6.7683 mL
15 mM 0.1805 mL 0.9024 mL 1.8049 mL 4.5122 mL
20 mM 0.1354 mL 0.6768 mL 1.3537 mL 3.3841 mL
25 mM 0.1083 mL 0.5415 mL 1.0829 mL 2.7073 mL
30 mM 0.0902 mL 0.4512 mL 0.9024 mL 2.2561 mL
40 mM 0.0677 mL 0.3384 mL 0.6768 mL 1.6921 mL
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Ochratoxin B Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ochratoxin B4825-86-9Endogenous Metabolitetoxic effectsratsHepG2MDCK cellsPKCRPTCInhibitorinhibitorinhibit

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