2. Immunology/Inflammation
  3. CD73
  4. Oleclumab

Oleclumab  (Synonyms: MEDI9447)

Cat. No.: HY-P99039 Pureza: 99.90%
COA
SDS
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Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.

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No. CAS : 1803176-05-7

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Based on 1 publication(s) in Google Scholar

Oleclumab Recomendaciones destacadas:

Oleclumab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Oleclumab

  • Actividad biológica

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Descripciòn

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity[1][2].

Isotype

Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

NT5E/CD73
In Vivo

Oleclumab (10 mg/kg; ip; every 3 days for 4 doses) increases the proportion of activated CD8+ lymphocyte populations in the mouse Balb/c syngeneic CT26 colon cancer tumor model. And Oleclumab significantly inhibits tumor growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine, Balb/c, syngeneic CT26 colon carcinoma tumor model[2]
Dosage: 10 mg/kg
Administration: ip; 2 time per week, for 2 weeks
Result: Inhibited tumor growth by 50% or greater from study day 7 to study day 16 when compared with isotype control antibody-treated groups.
Ensayo clínico
Gene ID

4907  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

143.14 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Oleclumab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized CD73/5'-Nucleotidase Protein, Human (HEK293, His, HY-P70010) can bind Oleclumab. The EC50 for this effect is 3.27 ng/mL.
  • Flow Cytometry analysis of A431 cells labelling NT5E/CD73 (red) with Oleclumab (anti-NT5E/CD73) (HY-P99039). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 lambda2 (HY-P990096). Black-Unlabelled control, cells without incubation with primary antibody.
Pureza y Documentación

Purity: 99.90%

SDS (251 KB)

COA (231 KB) SDS-PAGE (93 KB) SEC-HPLC (79 KB)

Inhibitory Antibodies User Guide (603 KB)
Referencias
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Oleclumab Related Classifications

  • Calculadora de molaridad

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleclumab1803176-05-7MEDI9447MEDI 9447MEDI-9447CD73ecto-5′-nucleotidase, NT5Ehuman IgG1λ anti-CD73 monoclonal antibodyanti-tumor activityInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Oleclumab
Cat. No.:
HY-P99039
Cantidad:
MCE Japan Authorized Agent:

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