2. Anti-infection
  3. Bacterial
  4. Oligopeptide-10

Oligopeptide-10 is a bioactive peptide with antimicrobial activity. Oligopeptide-10 exhibits broad-spectrum bactericidal effects against Gram-positive bacteria including Propionibacterium acnes and Staphylococcus aureus. Oligopeptide-10 targets lipoteichoic acid (LTA) on the surface of bacterial cell membranes, induces bacterial osmotic imbalance by disrupting the integrity of bacterial membranes, and reduces the release of pro-inflammatory cytokines induced by bacteria. Oligopeptide-10 possesses skin-protective activity. Oligopeptide-10 can be applied in research related to acne vulgaris, dandruff, seborrheic dermatitis, and tinea pedis.

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Synthèse de peptides personnalisée

Oligopeptide-10

Oligopeptide-10 Chemical Structure

CAS No. : 466691-40-7

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Oligopeptide-10 Related Antibodies

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Description

Oligopeptide-10 is a bioactive peptide with antimicrobial activity. Oligopeptide-10 exhibits broad-spectrum bactericidal effects against Gram-positive bacteria including Propionibacterium acnes and Staphylococcus aureus. Oligopeptide-10 targets lipoteichoic acid (LTA) on the surface of bacterial cell membranes, induces bacterial osmotic imbalance by disrupting the integrity of bacterial membranes, and reduces the release of pro-inflammatory cytokines induced by bacteria. Oligopeptide-10 possesses skin-protective activity. Oligopeptide-10 can be applied in research related to acne vulgaris, dandruff, seborrheic dermatitis, and tinea pedis[1][2][3].

In Vitro

Oligopeptide-10 exhibits broad-spectrum bactericidal effects against Gram-positive bacteria including Propionibacterium acnes and Staphylococcus aureus[1][3].
Oligopeptide-10 exhibits no cytotoxicity, irritation, sensitization, or mutagenicity in in vitro safety evaluations[1].
Oligopeptide-10 binds to lipoteichoic acid (LTA) on the bacterial surface, exerts antimicrobial activity, neutralizes pro-inflammatory bacterial components and reduces inflammatory responses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oligopeptide-10 Related Antibodies
Masse moléculaire

1598.07

Formule

C78H140N20O15
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Phe-Ala-Lys-Ala-Leu-Lys-Ala-Leu-Leu-Lys-Ala-Leu-Lys-Ala-Leu-NH2
Sequence Shortening

FAKALKALLKALKAL-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (62.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6258 mL 3.1288 mL 6.2575 mL
5 mM 0.1252 mL 0.6258 mL 1.2515 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6258 mL 3.1288 mL 6.2575 mL 15.6439 mL
5 mM 0.1252 mL 0.6258 mL 1.2515 mL 3.1288 mL
10 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5644 mL
15 mM 0.0417 mL 0.2086 mL 0.4172 mL 1.0429 mL
20 mM 0.0313 mL 0.1564 mL 0.3129 mL 0.7822 mL
25 mM 0.0250 mL 0.1252 mL 0.2503 mL 0.6258 mL
30 mM 0.0209 mL 0.1043 mL 0.2086 mL 0.5215 mL
40 mM 0.0156 mL 0.0782 mL 0.1564 mL 0.3911 mL
50 mM 0.0125 mL 0.0626 mL 0.1252 mL 0.3129 mL
60 mM 0.0104 mL 0.0521 mL 0.1043 mL 0.2607 mL
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Oligopeptide-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oligopeptide-10466691-40-7Oligopeptide10Oligopeptide 10Bacterialbacterial cell deathacne vulgarisinnate immunity peptide templateCutibacterium acnespro-inflammatory bacterial componentsdandrufflipoteichoic acidseborrheic dermatitistinea pedisInhibitorinhibitorinhibit

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