2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Dihydroorotate Dehydrogenase
  4. Olorofim

Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp..

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Olorofim

Olorofim 構造式

CAS 番号 : 1928707-56-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 757 在庫あり
Solution
10 mM * 1 mL in DMSO USD 757 在庫あり
Solid
1 mg $276 在庫あり
5 mg $690 在庫あり
10 mg $1150 在庫あり
25 mg $2070 在庫あり
50 mg $2690 在庫あり
100 mg $3300 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Olorofim 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp.[1].

IC50 & Target

Dihydroorotate dehydrogenase[1]
体外実験

Olorofim (0.1 μg/mL, 24-48 h) inhibits the spores germination and mycelium growth, exhibits antifungal activity against Aspergillus spp.[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olorofim 関連抗体
体内実験

Olorofim (15 mg/kg, ip, every 8 hours for 9 days) ameliorates chronic granulomatous disease (CGD), exhibits anti-infectious activity in Aspergillus-infected mouse models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aspergillus-infected mouse models[3]
Dosage: 15 mg/kg
Administration: ip, every 8 hours for 9 days
Result: Reduced granulomas and fungal hyphae in the lungs.
臨床実験
分子量

498.55

分子式

C28H27FN6O2
CAS 番号
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (200.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0058 mL 10.0291 mL 20.0582 mL
5 mM 0.4012 mL 2.0058 mL 4.0116 mL
10 mM 0.2006 mL 1.0029 mL 2.0058 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  5% DMSO    10% PEG400    85% (35% HP-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.01 mM); Clear solution

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0058 mL 10.0291 mL 20.0582 mL 50.1454 mL
5 mM 0.4012 mL 2.0058 mL 4.0116 mL 10.0291 mL
10 mM 0.2006 mL 1.0029 mL 2.0058 mL 5.0145 mL
15 mM 0.1337 mL 0.6686 mL 1.3372 mL 3.3430 mL
20 mM 0.1003 mL 0.5015 mL 1.0029 mL 2.5073 mL
25 mM 0.0802 mL 0.4012 mL 0.8023 mL 2.0058 mL
30 mM 0.0669 mL 0.3343 mL 0.6686 mL 1.6715 mL
40 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.2536 mL
50 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0029 mL
60 mM 0.0334 mL 0.1672 mL 0.3343 mL 0.8358 mL
80 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6268 mL
100 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.5015 mL
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Olorofim Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olorofim1928707-56-5F901318F 901318F-901318FungalDihydroorotate DehydrogenaseDHODHantifungalchronic granulomatous diseaseCGDanti-infectiousInhibitorinhibitorinhibit

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製品名:
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製品番号:
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