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Cat. No.: HY-104029R

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Olorofim (Standard)

(Synonyms: F901318 (Standard))

Olorofim (Standard) is the analytical standard of Olorofim (HY-104029). This product is intended for research and analytical applications. Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp..

For research use only. We do not sell to patients.

CAS No.: 1928707-56-5
Formula: C₂₈H₂₇FN₆O₂
Molecular Weight:498.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Olorofim (Standard) Chemical Structure

CAS No.: 1928707-56-5

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1928707-56-5
Molecular Weight 498.55
Formula C₂₈H₂₇FN₆O₂
SMILES

O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O
Synonyms

F901318 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lackner M, et al. Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei. J Antimicrob Chemother. 2018 Nov 1;73(11):3068-3073. [Content Brief]

[2]. du Pré S, et al., Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00231-18. [Content Brief]

[3]. Seyedmousavi S, et al., Efficacy of Olorofim (F901318) against Aspergillus fumigatus, A. nidulans, and A. tanneri in Murine Models of Profound Neutropenia and Chronic Granulomatous Disease. Antimicrob Agents Chemother. 2019 May 24;63(6):e00129-19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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