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Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp..

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Olorofim Chemical Structure

Olorofim Chemical Structure

CAS No. : 1928707-56-5

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10 mg USD 1150 In-stock
25 mg USD 2250 In-stock
50 mg USD 3550 In-stock
100 mg USD 5650 In-stock
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Based on 1 publication(s) in Google Scholar

Olorofim Related Antibodies

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Description

Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp.[1].

IC50 & Target

Dihydroorotate dehydrogenase[1]
Molecular Weight

498.55

Formula

C28H27FN6O2
CAS No.
Appearance

Solid

SMILES

O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (200.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0058 mL 10.0291 mL 20.0582 mL
5 mM 0.4012 mL 2.0058 mL 4.0116 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0058 mL 10.0291 mL 20.0582 mL 50.1454 mL
5 mM 0.4012 mL 2.0058 mL 4.0116 mL 10.0291 mL
10 mM 0.2006 mL 1.0029 mL 2.0058 mL 5.0145 mL
15 mM 0.1337 mL 0.6686 mL 1.3372 mL 3.3430 mL
20 mM 0.1003 mL 0.5015 mL 1.0029 mL 2.5073 mL
25 mM 0.0802 mL 0.4012 mL 0.8023 mL 2.0058 mL
30 mM 0.0669 mL 0.3343 mL 0.6686 mL 1.6715 mL
40 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.2536 mL
50 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0029 mL
60 mM 0.0334 mL 0.1672 mL 0.3343 mL 0.8358 mL
80 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6268 mL
100 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.5015 mL
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Olorofim Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olorofim1928707-56-5F901318F 901318F-901318OthersInhibitorinhibitorinhibit

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