2. Protein Tyrosine Kinase/RTK
  3. PDGFR FLT3
  4. PDGFRα/FLT3-ITD-IN-1

PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia.

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PDGFRα/FLT3-ITD-IN-1

PDGFRα/FLT3-ITD-IN-1 Chemical Structure

CAS No. : 2761259-05-4

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PDGFRα/FLT3-ITD-IN-1 Related Antibodies

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Description

PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].

Cellular Effect
Cell Line Type Value Description References
EOL1 GI50
0.015 3
Compound: 12d
Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein
Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein
[PMID: 35124201]
EOL1 GI50
0.015 3
Compound: 12d
Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein
Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein
[PMID: 35124201]
K562 GI50
10.756 3
Compound: 12d
Antiproliferative activity against human K562 cells
Antiproliferative activity against human K562 cells
[PMID: 35124201]
K562 GI50
10.756 3
Compound: 12d
Antiproliferative activity against human K562 cells
Antiproliferative activity against human K562 cells
[PMID: 35124201]
Kasumi 1 GI50
4.049 3
Compound: 12d
Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant
Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant
[PMID: 35124201]
Kasumi 1 GI50
4.049 3
Compound: 12d
Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant
Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant
[PMID: 35124201]
MV4-11 GI50
0.023 3
Compound: 12d
Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant
Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant
[PMID: 35124201]
MV4-11 GI50
0.023 3
Compound: 12d
Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant
Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant
[PMID: 35124201]
Masse moléculaire

505.66

Formule

C27H39N9O
CAS No.
SMILES

NCCCCNC(C1=CC=C(C=C1)NC2=NC(N[C@@H]3CC[C@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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PDGFRα/FLT3-ITD-IN-1 Related Classifications

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDGFRα/FLT3-ITD-IN-12761259-05-4PDGFRFLT3Platelet-derived growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3PDGFRαacute myeloid leukemiachronic eosinophilic leukemiaInhibitorinhibitorinhibit

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