2761259-05-4
2761259-05-4
Chemical Structure
PDGFRα/FLT3-ITD-IN-1
- CAS No.: 2761259-05-4
- Formula:C27H39N9O
- Molecular Weight:505.66
IUPAC Name: N-(4-aminobutyl)-4-((2-(((1r,4r)-4-aminocyclohexyl)amino)-9-cyclopentyl-9H-purin-6-yl)amino)benzamide
InChIKey: RBARWKMXQSXULQ-XUTJKUGGSA-N
SMILES: NCCCCNC(C1=CC=C(C=C1)NC2=NC(N[C@@H]3CC[C@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
Biological Activity: PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].
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PDGFRα/FLT3-ITD-IN-1 | PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia. | |||||||||||||||||||||
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References
Keywords
