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Cat. No.: HY-145902

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PDGFRα/FLT3-ITD-IN-1

PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia.

For research use only. We do not sell to patients.

CAS No.: 2761259-05-4
Formula: C₂₇H₃₉N₉O
Molecular Weight:505.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PDGFRα/FLT3-ITD-IN-1 Chemical Structure

CAS No.: 2761259-05-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All PDGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
EOL1	GI₅₀	0.015 μM Compound: 12d	Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein	[PMID: 35124201]
K562	GI₅₀	10.756 μM Compound: 12d	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 35124201]
Kasumi 1	GI₅₀	4.049 μM Compound: 12d	Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant	[PMID: 35124201]
MV4-11	GI₅₀	0.023 μM Compound: 12d	Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant	[PMID: 35124201]

Chemical Information

CAS No. 2761259-05-4
Molecular Weight 505.66
Formula C₂₇H₃₉N₉O
SMILES

NCCCCNC(C1=CC=C(C=C1)NC2=NC(N[C@@H]3CC[C@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PDGFRα/FLT3-ITD-IN-1

All PDGFR Isoforms