Penicillin amidase, E. coli (Immobilized)  (Synonyms: PGA)

Penicillin amidase, E. coli (Immobilized) (PGA) is an amidohydrolase commonly used in industrial biocatalysis. Penicillin amidase, E. coli (Immobilized) serves as a starting material in the synthesis of semi-synthetic penicillins. Penicillin amidase, E. coli (Immobilized) promotes the production of semi-synthetic β-lactam antibiotics, participates in peptide synthesis, and catalyzes the formation of chiral compounds. Penicillin amidase, E. coli (Immobilized) is regulated by temperature and phenylacetic acid in E. coli. In free E. coli, it participates in the assimilation of aromatic compounds as a carbon source. Penicillin amidase, E. coli (Immobilized) is hypothesized to act as a scavenging enzyme for phenylacetyl-containing compounds in microbial metabolism and is associated with bacterial quorum sensing^[1][2][3].

Penicillin amidase, E. coli (Immobilized) is a starting material in the synthesis of semi-synthetic penicillin, which can promote the production of semi-synthetic β-lactam antibiotics, participate in peptide synthesis, and catalyze the generation of chiral compounds^[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9014-06-6

Solid

White to light brown

[Penicillin amidase, E. coli (Immobilized)]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Duggleby HJ, et al. Penicillin acylase has a single-amino-acid catalytic centre. Nature. 1995 Jan 19;373(6511):264-8.  [Content Brief]

  [2]. Tishkov VI, et al. Protein engineering of penicillin acylase. Acta Naturae. 2010 Jul;2(3):47-61. PMID: 22649651; PMCID: PMC3347563.  [Content Brief]

  [3]. Avinash VS, et al. Penicillin acylases revisited: importance beyond their industrial utility. Crit Rev Biotechnol. 2016;36(2):303-316.  [Content Brief]