9014-06-6
Chemical Structure
Penicillin amidase, E. coli (Immobilized)
Synonym(s): PGA
- CAS No.: 9014-06-6
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Penicillin amidase, E. coli (Immobilized)]
Biological Activity: Penicillin amidase, E. coli (Immobilized) (PGA) is an amidohydrolase commonly used in industrial biocatalysis. Penicillin amidase, E. coli (Immobilized) serves as a starting material in the synthesis of semi-synthetic penicillins. Penicillin amidase, E. coli (Immobilized) promotes the production of semi-synthetic β-lactam antibiotics, participates in peptide synthesis, and catalyzes the formation of chiral compounds. Penicillin amidase, E. coli (Immobilized) is regulated by temperature and phenylacetic acid in E. coli. In free E. coli, it participates in the assimilation of aromatic compounds as a carbon source. Penicillin amidase, E. coli (Immobilized) is hypothesized to act as a scavenging enzyme for phenylacetyl-containing compounds in microbial metabolism and is associated with bacterial quorum sensing[1][2][3].
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Penicillin amidase, E. coli (Immobilized) | Penicillin amidase, E. coli (Immobilized) (PGA) is an amidohydrolase commonly used in industrial biocatalysis. Penicillin amidase, E. coli (Immobilized) serves as a starting material in the synthesis of semi-synthetic penicillins. Penicillin amidase, E. coli (Immobilized) promotes the production of semi-synthetic β-lactam antibiotics, participates in peptide synthesis, and catalyzes the formation of chiral compounds. Penicillin amidase, E. coli (Immobilized) is regulated by temperature and phenylacetic acid in E. coli. In free E. coli, it participates in the assimilation of aromatic compounds as a carbon source. Penicillin amidase, E. coli (Immobilized) is hypothesized to act as a scavenging enzyme for phenylacetyl-containing compounds in microbial metabolism and is associated with bacterial quorum sensing. | |||||||||||||||||||||
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- [1]. Duggleby HJ, et al. Penicillin acylase has a single-amino-acid catalytic centre. Nature. 1995 Jan 19;373(6511):264-8. [Content Brief]
- [2]. Tishkov VI, et al. Protein engineering of penicillin acylase. Acta Naturae. 2010 Jul;2(3):47-61. PMID: 22649651; PMCID: PMC3347563. [Content Brief]
- [3]. Avinash VS, et al. Penicillin acylases revisited: importance beyond their industrial utility. Crit Rev Biotechnol. 2016;36(2):303-316. [Content Brief]
