2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Apoptosis
  3. Histamine Receptor Apoptosis
  4. Pheniramine

Pheniramine  (Synonyms: Prophenpyridamine; Tripoton; Pheniramine solution)

Cat. No.: HY-B0971A
Handling Instructions Technical Support

Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects.

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Pheniramine

Pheniramine 화학구조

CAS No. : 86-21-5

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Pheniramine Related Antibodies

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제품 설명

Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects[1][2][3][4].

IC50 & Target

H1 Receptor

1.01 mM (IC50)

In Vitro

Pheniramine inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects[1].
Pheniramine inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM and regulates cellular Ca2+ transmembrane action[2].
Pheniramine (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines[3].
Pheniramine (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pheniramine Related Antibodies

Apoptosis Analysis[3]

Cell Line: Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL
Concentration: 0.5, 1.0 mM
Incubation Time: 24 hours
Result: Induced cells apoptosis with chromatin condenses and marginalizes, and nuclear debris spreaded into the cytoplasm.

Cell Viability Assay[3]

Cell Line: Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL
Concentration: 1 μM-1 mM
Incubation Time: 12, 24, 48 hours
Result: Inhibited cell proliferation and survival in a time- and dose-dependent manner.
In Vivo

Pheniramine (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague–Dawley rats (300-350 g; male)[4]
Dosage: 0.30, 0.60, 0.90, 1.50, 1.75 μM
Administration: Intrathecal injection; one time
Result: Resulted the spinal block and displayed dose-dependent effect.
Showed 100% blockades in motor function, proprioception, and nociception, with full recoveryduration of action about 41, 56, and 88 min, respectively, at 1.75 μM.
Clinical Trial
분자량

240.34

화학식

C16H20N2
CAS No.
SMILES

CN(CCC(C1=CC=CC=N1)C2=CC=CC=C2)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Pheniramine Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pheniramine86-21-5Prophenpyridamine Tripoton Pheniramine solutionHistamine ReceptorApoptosisantiemeticsedativehypnoticlumbar punctureantipruriticcentral nervous systemCNSfirst-generationCa2+ influxhuman T-cell acute lymphoblastic leukemiaCCRF-CEMJurkat ALLBC3H-1spinal blockInhibitorinhibitorinhibit

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Pheniramine
Cat. No.:
HY-B0971A
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