2. Others NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection
  3. SOD Fungal Reactive Oxygen Species (ROS) Environmental Pollutants
  4. Picoxystrobin

ピコキシストロビン  (Synonyms: Picoxystrobin)

製品番号: HY-136355 純度: 99.76%
COA 取扱説明書 Technical Support

Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.

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Picoxystrobin

ピコキシストロビン 構造式

CAS 番号 : 117428-22-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
100 mg $50 在庫あり
250 mg $85 在庫あり
500 mg $115 在庫あり
1 g $150 在庫あり
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ピコキシストロビン 関連抗体

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製品説明

Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity[1][2].

体内実験

Picoxystrobin (0-400 μg/L; waterborne exposure; 24-144 h) causes dose- and time-dependent changes in mortality, hatching rate and teratogenic rate in zebrafish embryos, and the 144-h LC50 is 213.8 μg/L[1].
Picoxystrobin (60-105 µg/L; waterborne exposure; 96 h) causes developmental toxicity, oxidative stress and immunotoxicity in zebrafish embryos[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type AB-strain zebrafish embryos[2]
Dosage: 60, 69, 79, 91, 105 µg/L
Administration: Embryos at 2 hpf were exposed to picoxystrobin solutions in 24-well culture plates (1 embryo per well), and the exposure solution was renewed every 24 h for 96 h
Result: Showed high toxicity to zebrafish embryos with a 96-h LC50 of 86 µg/L, causing decreased heartbeat, hatching inhibition, growth regression, morphological deformities, increased ROS and MDA contents, decreased SOD activity and GSH content, induced CAT activity, and altered expressions of genes related to antioxidant system and innate immune system.
分子量

367.32

分子式

C18H16F3NO4
CAS 番号
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(OC)/C(C(C=CC=C1)=C1COC2=CC=CC(C(F)(F)F)=N2)=C/OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (272.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7224 mL 13.6121 mL 27.2242 mL
5 mM 0.5445 mL 2.7224 mL 5.4448 mL
10 mM 0.2722 mL 1.3612 mL 2.7224 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7224 mL 13.6121 mL 27.2242 mL 68.0605 mL
5 mM 0.5445 mL 2.7224 mL 5.4448 mL 13.6121 mL
10 mM 0.2722 mL 1.3612 mL 2.7224 mL 6.8061 mL
15 mM 0.1815 mL 0.9075 mL 1.8149 mL 4.5374 mL
20 mM 0.1361 mL 0.6806 mL 1.3612 mL 3.4030 mL
25 mM 0.1089 mL 0.5445 mL 1.0890 mL 2.7224 mL
30 mM 0.0907 mL 0.4537 mL 0.9075 mL 2.2687 mL
40 mM 0.0681 mL 0.3403 mL 0.6806 mL 1.7015 mL
50 mM 0.0544 mL 0.2722 mL 0.5445 mL 1.3612 mL
60 mM 0.0454 mL 0.2269 mL 0.4537 mL 1.1343 mL
80 mM 0.0340 mL 0.1702 mL 0.3403 mL 0.8508 mL
100 mM 0.0272 mL 0.1361 mL 0.2722 mL 0.6806 mL
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Picoxystrobin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Picoxystrobin117428-22-5SODFungalReactive Oxygen Species (ROS)Environmental PollutantsSuperoxide DismutaseEnvironmental ContaminantsStrobilurinfungicideplantmitochondrialrespirationcytochrome-bcytochrome-c1oxidativezebrafish embryosInhibitorinhibitorinhibit

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