Poly-L-ornithine hydrochloride (MW 15000-30000)  (Synonyms: L-Ornithine homopolymer hydrochloride (MW 15000-30000))

Poly-L-ornithine hydrochloride (MW 15000-30000) is a polycationic homopolymer composed of L-ornithine. Poly-L-ornithine hydrochloride (MW 15000-30000) adsorbs negatively charged species through electrostatic interactions. Poly-L-ornithine hydrochloride (MW 15000-30000) can be used as a key component of polyelectrolyte complexes to construct core-shell structure carriers to achieve controlled delivery of growth factors (such as rhBMP-2, FGF-1). Poly-L-ornithine hydrochloride (MW 15000-30000) is used in the study of diabetes and bone regeneration related diseases^{[1][2][3][4][5]}.

Poly-L-ornithine (MW 15000-30000) (0.1%) hydrochloride significantly decreases viability of C₂C¹² myoblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Poly-L-ornithine hydrochloride (MW 15000-30000)-based multilayer alginate microcapsules (100 microcapsules/rat; implantation) enhance neovascularization with vessel density of 198.8 mm² in a rat omentum pouch model via FGF-1 delivery^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

15000-30000

(C₅H₁₂N₂O₂)n.xHCl

26982-21-8

Solid

White to off-white

CC([C@@H](N)CCCNC)=O.[n].[x].Cl

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Abbah SA, et al. In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template. J Control Release. 2012 Sep 10;162(2):364-72.  [Content Brief]

  [2]. McQuilling JP, et al. New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch. Transplant Proc. 2011 Nov;43(9):3262-4.  [Content Brief]

  [3]. Somo SI, et al. Dual Crosslinking of Alginate Outer Layer Increases Stability of Encapsulation System. Front Chem. 2020 Nov 12;8:575278.  [Content Brief]

  [4]. Kamiya Y, et al. Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer. Biol Pharm Bull. 2017;40(2):205-211.  [Content Brief]

  [5]. Khan AN, et al. Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases. J Biol Chem. 2006 Apr 28;281(17):11702-11.  [Content Brief]