26982-21-8
Chemical Structure
Poly-L-ornithine hydrochloride (MW 15000-30000)
Synonym(s): L-Ornithine homopolymer hydrochloride (MW 15000-30000)
- CAS No.: 26982-21-8
- Formula:(C5H12N2O2)n.xHCl
- Molecular Weight:15000-30000
SMILES: CC([C@@H](N)CCCNC)=O.[n].[x].Cl
Biological Activity: Poly-L-ornithine hydrochloride (MW 15000-30000) is a polycationic homopolymer composed of L-ornithine. Poly-L-ornithine hydrochloride (MW 15000-30000) adsorbs negatively charged species through electrostatic interactions. Poly-L-ornithine hydrochloride (MW 15000-30000) can be used as a key component of polyelectrolyte complexes to construct core-shell structure carriers to achieve controlled delivery of growth factors (such as rhBMP-2, FGF-1). Poly-L-ornithine hydrochloride (MW 15000-30000) is used in the study of diabetes and bone regeneration related diseases[1][2][3][4][5].
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Poly-L-ornithine hydrochloride (MW 15000-30000) | Poly-L-ornithine hydrochloride (MW 15000-30000) is a polycationic homopolymer composed of L-ornithine. Poly-L-ornithine hydrochloride (MW 15000-30000) adsorbs negatively charged species through electrostatic interactions. Poly-L-ornithine hydrochloride (MW 15000-30000) can be used as a key component of polyelectrolyte complexes to construct core-shell structure carriers to achieve controlled delivery of growth factors (such as rhBMP-2, FGF-1). Poly-L-ornithine hydrochloride (MW 15000-30000) is used in the study of diabetes and bone regeneration related diseases. | |||||||||||||||||||||
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References
- [1]. Abbah SA, et al. In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template. J Control Release. 2012 Sep 10;162(2):364-72. [Content Brief]
- [2]. McQuilling JP, et al. New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch. Transplant Proc. 2011 Nov;43(9):3262-4. [Content Brief]
- [3]. Somo SI, et al. Dual Crosslinking of Alginate Outer Layer Increases Stability of Encapsulation System. Front Chem. 2020 Nov 12;8:575278. [Content Brief]
- [4]. Kamiya Y, et al. Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer. Biol Pharm Bull. 2017;40(2):205-211. [Content Brief]
- [5]. Khan AN, et al. Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases. J Biol Chem. 2006 Apr 28;281(17):11702-11. [Content Brief]
