2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Autophagy Reactive Oxygen Species (ROS)
  4. Pyridinium bisretinoid A2E TFA

Pyridinium bisretinoid A2E TFA  (Synonyms: A2E TFA; N-retinylidene-N-retinylethanolamine TFA)

Art. -Nr.: HY-134928A Reinheit: 90.0%
COA
SDS
Handling Instructions Technical Support

Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Pyridinium bisretinoid A2E TFA

Pyridinium bisretinoid A2E TFA Chemische Struktur

CAS. Nr. : 1821308-73-9

Größe Preis Verfügbarkeit Menge
1 mg Auf Lager
5 mg Auf Lager
10 mg Auf Lager
25 mg Auf Lager
50 mg Auf Lager
100 mg Auf Lager
200 mg   Angebot einholen  
500 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 Customer Validation

Other Forms of Pyridinium bisretinoid A2E TFA:

Pyridinium bisretinoid A2E TFA Related Antibodies

Top Publications Citing Use of Products

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases[1][2].

In Vitro

Exposure of Pyridinium bisretinoid A2E (A2E) to light triggers its conversion into at least two products. One of these is epoxy-A2E, which is hydrophilic and can be transferred from the membrane to an aqueous solution. The other product is an unidentified hydrophobic substance[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridinium bisretinoid A2E TFA Related Antibodies
Molekulargewicht

705.93

Formel

C44H58F3NO3
CAS. Nr.
Appearance

Solid

Color

Brown to red

SMILES

OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C.O=C([O-])C(F)(F)F
Versand

Shipping with dry ice.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (141.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4166 mL 7.0829 mL 14.1657 mL
5 mM 0.2833 mL 1.4166 mL 2.8331 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 90.0%

SDS (393 KB)

COA (244 KB) HNMR (305 KB) LCMS (110 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4166 mL 7.0829 mL 14.1657 mL 35.4143 mL
5 mM 0.2833 mL 1.4166 mL 2.8331 mL 7.0829 mL
10 mM 0.1417 mL 0.7083 mL 1.4166 mL 3.5414 mL
15 mM 0.0944 mL 0.4722 mL 0.9444 mL 2.3610 mL
20 mM 0.0708 mL 0.3541 mL 0.7083 mL 1.7707 mL
25 mM 0.0567 mL 0.2833 mL 0.5666 mL 1.4166 mL
30 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1805 mL
40 mM 0.0354 mL 0.1771 mL 0.3541 mL 0.8854 mL
50 mM 0.0283 mL 0.1417 mL 0.2833 mL 0.7083 mL
60 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL
80 mM 0.0177 mL 0.0885 mL 0.1771 mL 0.4427 mL
100 mM 0.0142 mL 0.0708 mL 0.1417 mL 0.3541 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Pyridinium bisretinoid A2E TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridinium bisretinoid A2E1821308-73-9A2EN-retinylidene-N-retinylethanolamineApoptosisAutophagyReactive Oxygen Species (ROS)ROSblue-lightPhotoactivationInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
Pyridinium bisretinoid A2E TFA
Art. -Nr.:
HY-134928A
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.