Quinethazone

Art. -Nr.: HY-B1364: Data Sheet
COA

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Handling Instructions
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Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research.

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Quinethazone Chemische Struktur

CAS. Nr. : 73-49-4

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This product is a controlled substance and not for sale in your territory.

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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Beschreibung

Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research^[1]^[2].

In Vivo

Quinethazone (50 mg/kg; p.o.; daily for 2 weeks) lowers blood pressure of renal hypertensive rats in association with a decrease in potassium but no change in water or sodium contents of aorta wall^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Five- to 6-week-old Long Evans male rats, hypertension model^[1]
Dosage:	50 mg/kg
Administration:	Oral, daily for 2 weeks
Result:	Had no significant effect on sodium or water distribution in arterial tissue of hypertensive rats, but decreased approximate 20% intra-cellular content of potassium

Molekulargewicht

289.74

Formel

C₁₀H₁₂ClN₃O₃S

CAS. Nr.

73-49-4

Appearance

Solid

Color

Light brown to brown

SMILES

O=S(C1=CC2=C(NC(CC)NC2=O)C=C1Cl)(N)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Purity: 97.37%

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Data Sheet (270 KB) SDS (393 KB)

COA (250 KB) HNMR (261 KB) RP-HPLC (217 KB) MS (351 KB)

Handling Instructions (2659 KB)

Verweise

[1]. FREED SC. MECHANISM OF ANTI-HYPERTENSIVE ACTION OF QUINETHAZONE. Proc Soc Exp Biol Med. 1963 Nov;114:421-2. [Content Brief]

[2]. Angelopoulos B, et al. Experimental investigation and observations on the diuretic action of quinethazone. Med Pharmacol Exp Int J Exp Med. 1966;14(6):528-36. [Content Brief]

Quinethazone Related Classifications

Cardiovascular Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinethazone73-49-4Carbonic AnhydraseCarbonate dehydratasehypertensiondiureticpotassiumInhibitorinhibitorinhibit

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Quinethazone

Quinethazone Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Quinethazone Related Classifications

Molaritätsrechner

Verdünnungsrechner