2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. (R,R)-THC

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6.

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(R,R)-THC

(R,R)-THC Chemische Struktur

CAS. Nr. : 221368-54-3

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Other Forms of (R,R)-THC:

(R,R)-THC Related Antibodies

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Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Beschreibung

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].

IC50 & Target[1]

ERα

9.0 nM (Ki)

ERβ

3.6 nM (Ki)

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
8.6 μM
Compound: 14
Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay
Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay
[PMID: 23688559]
Molekulargewicht

320.42

Formel

C22H24O2
CAS. Nr.
Appearance

Solid

Color

Light yellow to brown

SMILES

OC(C=C1C[C@H]2CC)=CC=C1C3=C2C4=C(C=C(O)C=C4)C[C@H]3CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation
Verweise
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(R,R)-THC Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-THC221368-54-3Estrogen Receptor/ERRTetrahydrochryseneRelative binding affinityInhibitorinhibitorinhibit

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