Ractopamine hydrochloride (Synonyms: LY031537)

Name: Ractopamine hydrochloride
Brand: MedChemExpress
SKU: HY-B1421
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Art. -Nr.: HY-B1421 Reinheit: 99.2%: Data Sheet
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Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs.

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Ractopamine hydrochloride Chemische Struktur

CAS. Nr. : 90274-24-1

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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Other Forms of Ractopamine hydrochloride:

Ractopamine-d₃ (hydrochloride) In-stock
Ractopamine-d₆ hydrochloride Angebot einholen
Ractopamine-d₉ hydrochloride Angebot einholen
Ractopamine-d₅ hydrochloride Angebot einholen
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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

α adrenergic receptor β adrenergic receptor

Biologische Aktivität
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Beschreibung

In Vitro

Ractopamine (50 nM-100 μM) hydrochloride acts as a full agonist of mouse trace amine-associated receptor 1 (mTAAR1) in Xenopus laevis oocytes coexpressing hCFTR and mTAAR1, with an EC₅₀ of 16 μM, via a cAMP-dependent pathway^[1].
Ractopamine hydrochloride increases protein accumulation and synthesis in postfusion ELC₅ myotubes in a concentration-dependent manner^[3].
Ractopamine hydrochloride shows K_d value of ~25 nM for pig β1AR and β2AR^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ractopamine (5-10 mg/kg; oral; divided into 3 daily portions; 28 days) hydrochloride supplementation in finishing pigs causes minimal changes to specific behaviors, no changes to stress-related cortisol or lactate levels or skin/carcass lesions, but doubles serum creatine kinase concentrations, indicating potential muscular effects^[2].
Ractopamine (5-20 mg/kg; p.o.; daily; 48 days) hydrochloride administered in the diet of finishing swine linearly improves average daily gain, increases carcass weight and loin eye are^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	crossbred Camborough 25 × AGPIC 337 (170 barrows, 170 gilts, average initial body weight 107.3 kg)^[2]
Dosage:	5 mg/kg; 10 mg/kg
Administration:	oral; divided into 3 daily portions; 28 days
Result:	Increased the average percentage of pigs nosing pen mates to 6.73% (vs control 5.62%) at 5 mg/kg. Reduced the average percentage of pigs playing to 0.06% (vs control 0.26%) at 5 mg/kg. Increased the average percentage of pigs drinking water to 2.06% (vs control 1.58%) at 5 mg/kg. Increased the average percentage of pigs standing to 1.39% (vs control 0.85%) at 10 mg/kg. Increased serum CK-MB concentration to 4361 U/L (vs control 2341 U/L) and serum CK-total concentration to 12,436 U/L (vs control 5811 U/L) at 5 mg/kg. Increased serum CK-MB concentration to 4510 U/L (vs control 2341 U/L) and serum CK-total concentration to 10,707 U/L (vs control 5811 U/L) at 10 mg/kg. Showed no significant effect on overall pig behavior classification, skin/carcass lesions, blood cortisol or lactate concentrations.

Molekulargewicht

337.84

Formel

C₁₈H₂₄ClNO₃

CAS. Nr.

90274-24-1

Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(C)CCC1=CC=C(O)C=C1)C2=CC=C(O)C=C2.Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (296.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9600 mL	14.7999 mL	29.5998 mL
5 mM	0.5920 mL	2.9600 mL	5.9200 mL
10 mM	0.2960 mL	1.4800 mL	2.9600 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.2%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Liu X, et al. Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1. J Pharmacol Exp Ther. 2014;350(1):124-129. [Content Brief]

[2]. Athayde NB, et al. Stress susceptibility in pigs supplemented with ractopamine. J Anim Sci. 2013;91(9):4180-4187. [Content Brief]

[3]. Anderson PT, et al. Ractopamine increases total and myofibrillar protein synthesis in cultured rat myotubes. J Nutr. 1990;120(12):1677-1683. [Content Brief]

[4]. S. E. Mills, Biological basis of the ractopamine response, Journal of Animal Science, Volume 80, Issue E-suppl_2, 2002, Pages E28–E32

[5]. Stites CR, et al. The effect of ractopamine hydrochloride on the carcass cutting yields of finishing swine. J Anim Sci. 1991;69(8):3094-3101.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9600 mL	14.7999 mL	29.5998 mL	73.9995 mL
	5 mM	0.5920 mL	2.9600 mL	5.9200 mL	14.7999 mL
	10 mM	0.2960 mL	1.4800 mL	2.9600 mL	7.4000 mL
	15 mM	0.1973 mL	0.9867 mL	1.9733 mL	4.9333 mL
	20 mM	0.1480 mL	0.7400 mL	1.4800 mL	3.7000 mL
	25 mM	0.1184 mL	0.5920 mL	1.1840 mL	2.9600 mL
	30 mM	0.0987 mL	0.4933 mL	0.9867 mL	2.4667 mL
	40 mM	0.0740 mL	0.3700 mL	0.7400 mL	1.8500 mL
	50 mM	0.0592 mL	0.2960 mL	0.5920 mL	1.4800 mL
	60 mM	0.0493 mL	0.2467 mL	0.4933 mL	1.2333 mL
	80 mM	0.0370 mL	0.1850 mL	0.3700 mL	0.9250 mL
	100 mM	0.0296 mL	0.1480 mL	0.2960 mL	0.7400 mL

Ractopamine hydrochloride Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ractopamine90274-24-1LY031537LY 031537LY-031537Adrenergic ReceptorTrace Amine-associated Receptor (TAAR)Beta ReceptorβARadiposemuscletissue growthprotein metabolismpigInhibitorinhibitorinhibit

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Ractopamine hydrochloride (Synonyms: LY031537)

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Other Forms of Ractopamine hydrochloride:

Ractopamine hydrochloride Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Ractopamine hydrochloride Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Ractopamine hydrochloride Related Classifications

Keywords:

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