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Isoforms Recommended:	MRCK

Results for "

mrck

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cdc42-binding kinase (4) ROCK (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Cdc42-binding kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15392

Chroman 1 Maximum Cited Publications 70 Publications Verification	ROCK	Cardiovascular Disease
Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC₅₀=1 pM) than ROCK1 (IC₅₀=52 pM). Chroman 1 also has inhibitory activity against *MRCK, with an IC₅₀* of 150 nM .

HY-111424

BDP9066 3 Publications Verification	Cdc42-binding kinase	Cancer
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase *MRCK* inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

HY-12437

BDP5290	ROCK	Cancer
BDP5290 is a potent inhibitor of both ROCK and *MRCK* with IC₅₀s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

HY-15392A

Chroman 1 dihydrochloride Maximum Cited Publications 70 Publications Verification	ROCK	Cardiovascular Disease
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC₅₀=1 pM) than ROCK1 (IC₅₀=52 pM). Chroman 1 dihydrochloride also has inhibitory activity against *MRCK, with an IC₅₀* of 150 nM .

HY-125221

DJ4	ROCK Cdc42-binding kinase	Cancer
DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC₅₀ values:5 and 50 nM) and MRCKα/β (IC₅₀ values:10 and 100 nM). DJ4 blocks stress fiber formation and inhibits migration and invasion of cancer cells. DJ4 can be used for study of lung cancer, breast cancer, and pancreatic (PANC-1) cancer .

HY-111423

BDP8900	Cdc42-binding kinase	Cancer
BDP8900 is a potent and selective inhibitor of myotonic dystrophy-related Cdc42-binding kinases (MRCKα and MRCKβ). BDP8900 reduces substrate phosphorylation, leading to morphological changes, motility inhibition and invasiveness of cancer cells .

HY-111424A

(R)-BDP9066	Cdc42-binding kinase	Cancer
(R)-BDP9066 is an isomer of BDP9066 and has lower activity compared to BDP9066. BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 is derived from patent WO2019034890A1 (E118) .

HY-RS02301

CDC42BPA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC42BPA Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42BPA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC42BPA Human Pre-designed siRNA Set A CDC42BPA Human Pre-designed siRNA Set A

Species:	Human (4)
Tag:	His (1) Tag Free (1) Strep (1) GST (3)
Source:	sf9 insect cells (1) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701817

	MRCKα Protein, Human (Active, sf9, GST) CDC42BPA; Serine/threonine-protein kinase mrck alpha; CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; mrck alpha; Myotonic dystrophy protein kinase-like alpha	Human	Sf9 insect cells
	The MRCKα protein is a key serine/threonine protein kinase downstream of CDC42 that coordinates cytoskeletal dynamics and cell migration. MRCKα phosphorylates PPP1R12C and MYL9/MLC2, regulating actin reorganization. MRCKα Protein, Human (sf9, GST) is the recombinant human-derived MRCKα protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702635

	MRCKβ Protein, Human (sf9, GST) CDC42BPB; CDC42 binding protein kinase beta (DMPK-like); mrckB; KIAA1124; CDC42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; mrck beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Serine/threonine-protein kinase mrck beta	Human	Sf9 insect cells
	CDC42BPB protein is a key serine/threonine protein kinase downstream of CDC42 that controls cytoskeletal dynamics and cell migration. CDC42BPB phosphorylates PPP1R12C and MYL9/MLC2, regulates actin reorganization and shapes cell dynamics. MRCKβ Protein, Human (sf9, GST) is the recombinant human-derived MRCKβ, expressed by Sf9 insect cells, with GST labeled tag.

HY-P705758

	MRCKβ Protein, Human (Active, sf9, His-StrepII-GST) CDC42BPB; CDC42 binding protein kinase beta (DMPK-like); mrckB; KIAA1124; CDC42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; mrck beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Serine/threonine-protein kinase mrck beta	Human	sf9 insect cells

HY-P702634

	MRCKG Protein, Human (Active, sf9) CDC42BPG; CDC42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase mrck gamma; DMPK2; HSMDPKIN; kappa 200; mrckgamma; mrck gamma; DMPK-like gamma; CDC42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related CDC42-binding kinase gamma; mrckG; KAPPA-200	Human	Sf9 insect cells
	MRCKG Protein, Human (sf9) is the recombinant human-derived MRCKG, expressed by Sf9 insect cells , with tag Free labeled tag. ,

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (1) ICC/IF (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810947

	MRCK alpha Antibody KIAA0451, CDC42BPA, Serine/threonine-protein kinase mrck alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, mrck alpha, Myotonic dystrophy protein kinase-like alpha	WB, ICC/IF	Human, Mouse, Rat
	MRCK alpha Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MRCK alpha.

HY-P811207

	MRCK beta Antibody KIAA1124, CDC42BPB, Serine/threonine-protein kinase mrck beta, CDC42-binding protein kinase beta, DMPK-like beta, Myotonic dystrophy kinase-related CDC42-binding kinase beta, CDC42BP-beta, mrck beta, Myotonic dystrophy protein kinase-like beta	WB, IHC-P	Human, Mouse, Rat
	MRCK beta Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MRCK beta.

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Cat. No.	Product Name		Classification

HY-RS02301

CDC42BPA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CDC42BPA Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42BPA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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