DJ4
Based on 1 Customer Validation
DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and inhibits migration and invasion of cancer cells. DJ4 can be used for study of lung cancer, breast cancer, and pancreatic (PANC-1) cancer.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 1681020-24-5
- Formula: C19H16N4OS
- Molecular Weight:348.42
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Stem Cell Signaling Compound Library
HY-L017
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TGF-beta/Smad Compound Library
HY-L018
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Covalent Screening Library
HY-L036
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Reprogramming Compound Library
HY-L039
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Cytoskeleton Compound Library
HY-L060
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Lung Cancer Compound Library
HY-L075
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Anti-Pulmonary Fibrosis Compound Library
HY-L125
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Cancer Stem Cells Compound Library
HY-L135
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Extracellular Vesicles (EVs) Compound Library
HY-L168
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
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ROCK1 5 nM (IC50) |
ROCK2 50 nM (IC50) |
MRCKα 10 nM (IC50) |
MRCKβ 100 nM (IC50) |
DJ4 (2.5-5 µM; 24 h) inhibits migration and invasion of cancer cells[1].
DJ4 (2.5-5 µM; 24 h) blocks recombinant MYPT1 phosphorylation in A549 cells[1].
A549 cells[1]
2.5 µM, 5 µM
24 h
Effectively blocked recombinant MYPT1 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human lung (H522), breast (MDA-MB-231), and pancreatic (PANC-1) cancer cell lines
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Concentration:2.5 µM, 5 µM
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Incubation Time:24 h
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Result:Significantly inhibited migration of cancer cells.
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Cell Line:A549 cells
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Concentration:2.5 µM, 5 µM
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Incubation Time:24 h
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Result:Effectively blocked recombinant MYPT1 phosphorylation.
Chemical Information
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CAS No. 1681020-24-5
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Appearance Solid
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Molecular Weight 348.42
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Formula C19H16N4OS
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Color Off-white to light yellow
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SMILES
O=C1N/C(S/C1=C/C2=CNC3=C2C=CC=N3)=N\CCC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (28.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8701 mL | 14.3505 mL | 28.7010 mL | 71.7525 mL |
| 5 mM | 0.5740 mL | 2.8701 mL | 5.7402 mL | 14.3505 mL | |
| 10 mM | 0.2870 mL | 1.4350 mL | 2.8701 mL | 7.1752 mL | |
| 15 mM | 0.1913 mL | 0.9567 mL | 1.9134 mL | 4.7835 mL | |
| 20 mM | 0.1435 mL | 0.7175 mL | 1.4350 mL | 3.5876 mL | |
| 25 mM | 0.1148 mL | 0.5740 mL | 1.1480 mL | 2.8701 mL |
DJ4 Related Classifications
HY-125221 Related Classifications
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