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BDP9066 

Cat. No.: HY-111424
Handling Instructions

BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinases MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

For research use only. We do not sell to patients.

BDP9066 Chemical Structure

BDP9066 Chemical Structure

CAS No. : 2226507-04-4

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Description

BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinases MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

IC50 & Target

IC50: 64 nM (MRCKβin SCC12 cells), Ki: 0.0136 nM/ 0.0233 nM (MRCKα/β)[1].

In Vitro

BDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion[1].

In Vivo

BDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

348.44

Formula

C₂₀H₂₄N₆

CAS No.

2226507-04-4

SMILES

C12=C(N3CCC[[email protected]@]4(CCCCN4)C3)C=CNC1=NC=C2C5=NC=NC=C5

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Room temperature in continental US; may vary elsewhere

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BDP9066
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HY-111424
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BDP9066

Cat. No.: HY-111424