2. Immunology/Inflammation
  3. LAG-3
  4. Relatlimab

Relatlimab  (Synonyms: BMS-986016)

Cat. No.: HY-P99156 Purity: 98.00%
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SDS
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Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No. : 1673516-98-7

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Customer Review

Based on 3 publication(s) in Google Scholar

Relatlimab Featured Recommendations:

Relatlimab Related Antibodies

Top Publications Citing Use of Products

    Relatlimab purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jul 24;188(15):4025-4042.e20.  [Abstract]

    In the presence of HLA-DR1 HA306-318 aAPC, Relatlimab (anti-LAG-3) (20 μg/mL; 75 μL; 30 min; 37 ℃) reversed the LAG-3 overexpression-induced suppression of GFP reporter signal in human LAG-3-transduced Jurkat NFAT-GFP reporter T cells.

    Relatlimab purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jul 24;188(15):4025-4042.e20.  [Abstract]

    Relatlimab (anti-LAG-3) (20 μg/mL; 75 μL; 30 min; 37 ℃) blocked the LAG-3 CAR signal triggered by human pMHC class II.

    Relatlimab purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jul 24;188(15):4025-4042.e20.  [Abstract]

    Relatlimab (anti-LAG-3) (80 nM). The percentage of mCherry+ Lck and TCR-CD3 measured by anti-CD3ε antibody (OKT3, Alexa-647 labeled) co-localized with each other, and the number or size of the TCR clusters.

    Relatlimab purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Feb 10;11(1):58.  [Abstract]

    Relatlimab (1-100 nM) showed significant binding to recombinant LAG-3/Fc.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer[1].

    Isotype

    Human IgG4 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    LAG3/CD223
    In Vitro

    Relatlimab (BMS-986016; 0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and cynomolgus CD4+ T cells with EC50 values of 0.11 nM and 29.11 nM, respectively[1].
    Relatlimab (0.001-10000 nM; T cells (3A9-hLAG-3)) enhances peptide responsiveness of T-cell hybridoma 3A9-hLAG-3 and reversals LAG-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 with an IC50 value of 1.05 nM[1].
    Relatlimab (0.001-10000 nM; primary T cells) enhances activation of superantigen-stimulated human PBMC cultures and enhances IL-2 secretion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Relatlimab Related Antibodies
    Clinical Trial
    Gene ID

    3902  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    145.58 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Relatlimab]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG4 kappa
    Biological Activity
    • Flow cytometric analysis of 1X106 Jurkat cells with Relatlimab (HY-P99156, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
    • Loaded Relatlimab on AHC2 biosensor, can bind LAG-3 Protein, Human (HEK293, His, HY-P70722) with an affinity constant of 8.814E-10 M as determined in BLI assay.
    Purity & Documentation

    Purity: 98.00%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (111 KB) SEC-HPLC (181 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    • If you have published this work, please enter the PubMed ID.
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    Relatlimab Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Relatlimab1673516-98-7BMS-986016BMS986016BMS 986016LAG-3Lymphocyte activation gene-3CD223monoclonal antibodyCD4+ T cellsIL-2 secretionanticancernivolumabInhibitorinhibitorinhibit

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