Resiquimod (Synonyms: R848; S28463)

Name: Resiquimod
Brand: MedChemExpress
SKU: HY-13740G
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-13740G: Data Sheet
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Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages.

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Resiquimod Chemische Struktur

CAS. Nr. : 144875-48-9

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10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target^[1]

TLR7

TLR8

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.75 3 Compound: R848	Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	1.5 3 Compound: 2	Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	1.4 3 Compound: 2	Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
HEK293	EC₅₀	0.75 3 Compound: R848	Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	1.4 3 Compound: 2	Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
HEK293	EC₅₀	1.5 3 Compound: 2	Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	4.5 3 Compound: 2	Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	260.1 1 Compound: 2	Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay	[PMID: 20232824]
HEK293	EC₅₀	4 3 Compound: Resiquimod	Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay	[PMID: 27270029]
HEK293	EC₅₀	5.87 3 Compound: R848	Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	4.5 3 Compound: 2	Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	4 3 Compound: Resiquimod	Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay	[PMID: 27270029]
HEK293	EC₅₀	5.87 3 Compound: R848	Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	6.4 3 Compound: 2	Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
HEK293	EC₅₀	0.75 3 Compound: R848	Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	6.4 3 Compound: 2	Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
PBMC	EC₅₀	24 1 Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]
HEK293	EC₅₀	1.4 3 Compound: 2	Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
PBMC	EC₅₀	24 1 Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]
PBMC	EC₅₀	26.5 1 Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]
HEK293	EC₅₀	1.5 3 Compound: 2	Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	260.1 1 Compound: 2	Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay	[PMID: 20232824]
PBMC	EC₅₀	26.5 1 Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]
HEK293	EC₅₀	260.1 1 Compound: 2	Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay	[PMID: 20232824]
HEK293	EC₅₀	4 3 Compound: Resiquimod	Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay	[PMID: 27270029]
HEK293	EC₅₀	4.5 3 Compound: 2	Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	5.87 3 Compound: R848	Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	6.4 3 Compound: 2	Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
PBMC	EC₅₀	24 1 Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]
PBMC	EC₅₀	26.5 1 Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]

In Vitro

Resiquimod (GMP) (3 µg/mL, 5 days) induces human mMDSC to mature into inflammatory macrophage (MAC_inflam)^[1].
Resiquimod (GMP) (3 µg/mL, 3 days) produces IL-6 and IL-12 in human mMDSC^[1].
Resiquimod (GMP) (2.5 µg/mL, 7 days) transdifferentiaes memory B cells to IgG producing plasma cells^[2].
Resiquimod (GMP) (5 µg/mL, 5 days) induces the differentiation of MDSCs into mature myeloid cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

314.38

Formel

C₁₇H₂₂N₄O₂

CAS. Nr.

144875-48-9

Appearance

Solid

Color

White to off-white

SMILES

OC(C)(C)CN1C(COCC)=NC2=C1C3=CC=CC=C3N=C2N

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Data Sheet (276 KB) SDS (393 KB) Handling Instructions (2659 KB)

Verweise

[1]. Bayik D, et al. Factors Influencing the Differentiation of Human Monocytic Myeloid-Derived Suppressor Cells Into Inflammatory Macrophages. Front Immunol. 2018 Mar 26;9:608. [Content Brief]

[2]. Preisendörfer S, et al. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells. 2022 Apr 14;11(8):1341. [Content Brief]

[3]. Lee M, et al. Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch Pharm Res. 2014;37(9):1234-40. [Content Brief]

Resiquimod Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resiquimod (GMP)144875-48-9R848 (GMP)S28463 (GMP)Toll-like Receptor (TLR)GMPcell therapydifferentiationMDSCmacrophagemyeloid cellInhibitorinhibitorinhibit

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Resiquimod (Synonyms: R848; S28463)

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Resiquimod Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Resiquimod Related Antibodies

Resiquimod Related Classifications

Molaritätsrechner

Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

The dilution calculator equation

Keywords:

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