2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Rilotumumab

Rilotumumab  (Synonyms: AMG 102)

製品番号: HY-P99217 純度: 99.10%
COA Technical Support

Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research.

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CAS 番号 : 872514-65-3

容量 価格（税別） 在庫状況 数量
1 mg $310 在庫あり
5 mg $805 在庫あり
10 mg $1290 在庫あり
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100 mg   お問い合わせ  

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製品説明

Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research[1][2].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

HGF/SF
体外実験

Rilotumumab (10 μg/mL; overnight) shows the decrease of MET phosphorylation at Y1234 and Y1235, and an increase in total MET[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rilotumumab 関連抗体

Western Blot Analysis[2]

Cell Line: U87MG.vIII cells
Concentration: 10 μg/mL
Incubation Time: Overnight
Result: Showed MET phosphorylation at tyrosine residue 1234 (Y1234) and Y1235 ~50% lower in U87MG.vIII cells than in untreated cells.
Showed an increase in total MET compared with untreated cells.
体内実験

Rilotumumab (intraperitoneal injection; 1.5 mg/kg; once two days; 11 d) treatment inhibits glioma cell growth in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old BALB/c nu/nu female mice subcutaneous injected with U87MG.vIII cells[2]
Dosage: 1.5 mg/kg
Administration: Intraperitoneal injection; 1.5 mg/kg; once two days; 11 days
Result: Reduced U87MG.vIII xenograft growth (P=0.0002) compared with vehicle-treated xenografts (P=0.0001).
臨床実験
Gene ID

3082  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.2 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Rilotumumab]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized Human HGF Protein (C-6His) can bind Rilotumumab. The EC50 for this effect is 13.45 ng/mL.
純度とドキュメンテーション
参考文献
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Rilotumumab Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rilotumumab872514-65-3AMG 102AMG102AMG-102c-Met/HGFRhepatocyte growth factorcastration-resistant prostate cancerCRPCsolid tumorU87MG.vIII cellInhibitorinhibitorinhibit

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製品名:
Rilotumumab
製品番号:
HY-P99217
数量:
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