Rp-8-Br-cAMPS 

Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion^[1][2][3].

Rp-8-Br-cAMPS (1 mM; 4-6 h) completely blocks the ability of 2-chloroadenosine (HY-W008344) to inhibit LAK cytotoxicity, and significantly reduces the inhibitory effect of 2-chloroadenosine (HY-W008344) on cytokine production^[1].
Rp-8-Br-cAMPS (50-100 μM; 2 min) inhibits insulin secretion in 832/13 cells (derived from INS-1 cells)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rp-8-Br-cAMPS (1 mg; intraperitoneal injection; 10 days) improves immune function in a mouse retrovirus infection model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

424.17

C₁₀H₁₁BrN₅O₅PS

129735-00-8

NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S)=O)O3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Raskovalova T, et al. Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). Immunol Res. 2006;36(1-3):91-9.  [Content Brief]

  [2]. Yang S, et al. Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol. 2004 Sep;18(9):2312-20.  [Content Brief]

  [3]. Nayjib B, et al. In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell responses in retrovirus-infected mice[J]. The Open Immunology Journal, 2008, 1(1).