2. Metabolic Enzyme/Protease Anti-infection
  3. HIV Integrase HIV
  4. S 1360

S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants.

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S 1360

S 1360 Estructura química

No. CAS : 280571-30-4

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S 1360 Related Antibodies

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Descripciòn

S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants[1].

Cellular Effect
Cell Line Type Value Description References
PBMC CC50
110 3
Compound: S-1360
Cytotoxicity against PBMC
Cytotoxicity against PBMC
[PMID: 22328963]
PBMC CC50
110 3
Compound: S-1360
Cytotoxicity against PBMC
Cytotoxicity against PBMC
[PMID: 22328963]
Peso molecular

313.28

Fòrmula

C16H12FN3O3
No. CAS
SMILES

O=C(C1=CC=C(CC2=CC=C(C=C2)F)O1)/C=C(C3=NN=CN3)\O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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S 1360 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S 1360280571-30-4S1360S-1360HIV IntegraseHIVHuman immunodeficiency virusHIV-1 integraseMT-4 cellInhibitorinhibitorinhibit

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Nombre del producto:
S 1360
Cat. No.:
HY-12108
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