280571-30-4
Chemical Structure
S 1360
- CAS No.: 280571-30-4
- Formula:C16H12FN3O3
- Molecular Weight:313.28
IUPAC Name: (Z)-1-(5-(4-fluorobenzyl)furan-2-yl)-3-hydroxy-3-(1H-1,2,4-triazol-5-yl)prop-2-en-1-one
InChIKey: HFHDGHOGHWXXDT-ZSOIEALJSA-N
SMILES: O=C(C1=CC=C(CC2=CC=C(C=C2)F)O1)/C=C(C3=NN=CN3)\O
Biological Activity: S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants[1].
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S 1360 | S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants. | |||||||||||||||||||||
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