[S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10)

Name: [S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10)
Brand: MedChemExpress
SKU: HY-P11312
Rating: 4.5 (0 reviews)

Cat. No.: HY-P11312 Pureté: 98.14%: Fiche technique
COA

SDS
Instruction de manipulation
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[S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) is a neuropeptide A analog and a peptide fragment of EB1002 (HY-P10746). [S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) is highly selective for mouse tachykinin receptors and human tachykinin receptor NK1R.

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[S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) Chemical Structure

CAS No. : 2770688-17-8

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis
100 mg	Obtenir un devis

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Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Neurokinin Receptor:

Voir toutes les isoformes

NK1R NK2R NK3R

Activité biologique
Pureté et documentation
Références
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Description

IC₅₀ & Target^[1]

NK1R

In Vitro

EB1002 is a highly selective, long-acting NK2R agonist. EB1002 exerts central appetite suppression, increases peripheral energy expenditure and enhances insulin sensitivity, which effectively reduces body weight, improves glucose and lipid metabolism, with favorable safety profiles. EB1002 can be used for research on diseases such as obesity and type 2 diabetes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

821.96

Formule

C₃₈H₆₃N₉O₁₁

CAS No.

2770688-17-8

Appearance

Solid

Color

White to off-white

Sequence

Asp-Lys-Tyr-Val-Gly-{Leu(Me)}-{Hse(Me)}-NH2

Sequence Shortening

DKYVG-{Leu(Me)}-{Hse(Me)}-NH2

SMILES

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](C(C)C)C(NCC(N(C)[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCOC)=O)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](N)CC(O)=O)=O)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (60.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2166 mL	6.0830 mL	12.1660 mL
5 mM	0.2433 mL	1.2166 mL	2.4332 mL
10 mM	0.1217 mL	0.6083 mL	1.2166 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 98.14%

Select Batch:

Fiche technique (272 KB) SDS (252 KB)

COA (248 KB) LCMS (322 KB) Elemental Analysis Report (107 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Sass F, et al. NK2R control of energy expenditure and feeding to treat metabolic diseases. Nature. 2024;635(8040):987-1000. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2166 mL	6.0830 mL	12.1660 mL	30.4151 mL
	5 mM	0.2433 mL	1.2166 mL	2.4332 mL	6.0830 mL
	10 mM	0.1217 mL	0.6083 mL	1.2166 mL	3.0415 mL
	15 mM	0.0811 mL	0.4055 mL	0.8111 mL	2.0277 mL
	20 mM	0.0608 mL	0.3042 mL	0.6083 mL	1.5208 mL
	25 mM	0.0487 mL	0.2433 mL	0.4866 mL	1.2166 mL
	30 mM	0.0406 mL	0.2028 mL	0.4055 mL	1.0138 mL
	40 mM	0.0304 mL	0.1521 mL	0.3042 mL	0.7604 mL
	50 mM	0.0243 mL	0.1217 mL	0.2433 mL	0.6083 mL
	60 mM	0.0203 mL	0.1014 mL	0.2028 mL	0.5069 mL