2. GPCR/G Protein Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. Adrenergic Receptor ERK
  4. Salbutamol adipate

Salbutamol adipate  (Synonyms: Albuterol adipate; AH-3365 adipate)

製品番号: HY-B1037B
取扱説明書 Technical Support

Salbutamol (Albuterol) adipate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol adipate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol adipate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.

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CAS 番号 : 149234-08-2

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Salbutamol adipate 関連抗体

Top Publications Citing Use of Products

    Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.

    Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.

    Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.

    Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.

    Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.

    Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    α adrenergic receptor β adrenergic receptor

    ERK アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    ERK ERK1 ERK2 ERK5 ERK8

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    製品説明

    Salbutamol (Albuterol) adipate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol adipate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol adipate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease[1][2].

    IC50 & Target[1]

    β adrenergic receptor

     

    体外実験

    Salbutamol (16 μM; 24 h) adipate significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Salbutamol adipate 関連抗体

    Western Blot Analysis[1]

    Cell Line: MGC803, SGC7901
    Concentration: 16 μM
    Incubation Time: 24 h
    Result: Increased β2-AR and ERK levels.
    Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
    体内実験

    Salbutamol (5 mg/kg; oral administration; 2 weeks) adipate can increase tumor growth in nude mice with gastric cancer[1].
    Salbutamol (6 mg/kg; oral administration; 4 weeks) adipate has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Streptozotocin induced diabetic rats[2]
    Dosage: 6 mg/kg
    Administration: Oral administration (p.o.); 4 weeks
    Result: Enhanced muscle grip strength, coordination, and antioxidant levels.
    Reduced proinflammatory markers and oxidative stress.
    Reduced serum muscle biomarkers.
    Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
    分子量

    312.38

    分子式

    C13H21NO3.1/2C6H10O4
    CAS 番号
    SMILES

    O=C(CCCCC(O)=O)O.OC1=CC=C(C(CNC(C)(C)C)O)C=C1CO.[1/2]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
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    Salbutamol adipate Related Classifications

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    Keywords:

    Salbutamol149234-08-2AlbuterolAH-3365AH3365AH 3365Adrenergic ReceptorERKBeta ReceptorExtracellular signal regulated kinasesβ2-ARAgonistMGC803SGC7901COPDInhibitorinhibitorinhibit

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    製品名:
    Salbutamol adipate
    製品番号:
    HY-B1037B
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