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14-3-3ζ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (3) Estrogen Receptor/ERR (2) PROTACs (1) Ser/Thr Protease (1)
By Research Areas:	Cancer (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115501

(E)-FOBISIN101	Ser/Thr Protease	Cancer
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC₅₀ values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research .

HY-162838

TCF199	Estrogen Receptor/ERR	Others
TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ .

HY-171977

UTKO1	Drug Derivative	Cancer
UTKO1 (Compound 2) is a derivate of Moverastin.UTKO1 has optical activity and significant inhibitory activity against tumor cell migration by abrogating the binding of *14-3-3ζ/Tiam1*. UTKO1 can be used for cancers like esophageal cancer and epidermoid carcinoma research .

HY-179576

CV2a	PROTACs Estrogen Receptor/ERR	Others
CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC₅₀ of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex .

HY-181617

12-Hydroxyfusicoccin 12-hFC	Drug Derivative	Cancer
12-Hydroxyfusicoccin (12-hFC) is a Fusicoccin (HY-122815) derivative. 12-Hydroxyfusicoccin lacks antiproliferative activity and is inactive to protein-protein interactionin and protein synthesis in cancer cells .

HY-N19296

Blapsin B	Drug Derivative	Cancer
Blapsin B is a potent *14-3-3* inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC₅₀ value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N19296

Blapsin B	Structural Classification Animals Phenols Polyphenols Source Classification	Drug Derivative
Blapsin B is a potent *14-3-3* inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC₅₀ value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research .

Species:	Human (3) Mouse (1)
Tag:	His (2) Tag Free (1) GST (1)
Source:	Sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702997

	14-3-3 zeta Protein, Human 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	E. coli
	14-3-3 zeta Protein, Human is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with tag free labeled tag.

HY-P702996

	14-3-3 zeta Protein, Human (sf9, His) 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	Sf9 insect cells
	14-3-3 zeta Protein, Human (sf9, His) is the recombinant human-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P702995

	14-3-3 zeta Protein, Human (GST) Proto-oncogene vav; VAV1; VAV	Human	E. coli
	14-3-3 zeta Protein, Human (GST) is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with GST labeled tag.

HY-P703013

	14-3-3 zeta Protein, Mouse (sf9, His) 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1 (KCIP-1); SEZ-2; Ywhaz	Mouse	Sf9 insect cells
	14-3-3 zeta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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14-3-3ζ

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Natural
Products