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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
14-3-3ζ
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "14-3-3ζ" in MCE Product Catalog:
Cat. No.: HY-115501
CAS No.: 1370281-06-3
Target:
Research Areas:
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research .
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WS3 is an allosteric inhibitor of 14-3-3 (14-3-3ζ: Kd = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE signaling pathway (IC50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation . WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer .
Cat. No.: HY-162838
Target:
Research Areas:
TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ .
Cat. No.: HY-W678610
CAS No.: 136715-68-9
Target:
Research Areas:
14-3-3γ/SLP76 degrader-1 is a stabiliser of the 14-3-3γ/phosphorylated SLP76 protein-protein interaction. 14-3-3γ/SLP76 degrader-1 lacks stabilising activity on the unrelated IL17/IL17R protein-protein interaction. 14-3-3γ/SLP76 degrader-1 lacks stabilising activity on the 14-3-3ζ/p27 protein-protein interaction. 14-3-3γ/SLP76 degrader-1 can be used for the research of autoimmune and inflammatory conditions .
Cat. No.: HY-P702997
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: YWHAZ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta; YWHAD; KCIP-1; 14-3-3-Zeta; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein; Delta Polypeptide; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase
Species:
Human
Source:
E. coli
Cat. No.: HY-P702995
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YWHAZ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta; YWHAD; KCIP-1; 14-3-3-Zeta; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein; Delta Polypeptide; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase
Species:
Human
Source:
E. coli
Cat. No.: HY-P703013
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YWHAZ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta; YWHAD; KCIP-1; 14-3-3-Zeta; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein; Delta Polypeptide; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P702996
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YWHAZ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta; YWHAD; KCIP-1; 14-3-3-Zeta; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein; Delta Polypeptide; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activ
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-171977
CAS No.: 868136-01-0
Target:
Research Areas:
UTKO1 (Compound 2) is a derivate of Moverastin.UTKO1 has optical activity and significant inhibitory activity against tumor cell migration by abrogating the binding of 14-3-3ζ/Tiam1. UTKO1 can be used for cancers like esophageal cancer and epidermoid carcinoma research .
Cat. No.: HY-179576
Research Areas:
CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC50 of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex .
Cat. No.: HY-181617
CAS No.: 2281679-00-1
Synonyms: 12-hFC
Target:
Research Areas:
12-Hydroxyfusicoccin (12-hFC) is a Fusicoccin (HY-122815) derivative. 12-Hydroxyfusicoccin lacks antiproliferative activity and is inactive to protein-protein interactionin and protein synthesis in cancer cells .
Cat. No.: HY-N19296
CAS No.: 861145-00-8
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Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
