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  4. Blapsin B

Blapsin B is a potent 14-3-3 inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC50 value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research.

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Blapsin B

Blapsin B Chemical Structure

CAS No. : 861145-00-8

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Blapsin B Related Antibodies

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Description

Blapsin B is a potent 14-3-3 inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC50 value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research[1].

In Vitro

Blapsin B (10 μM) potently inhibits 14-3-3γ protein-protein interactions in an ELISA assay with an IC50 of 10.0 μM[1].
Blapsin B (2.5 μM) potently inhibits 14-3-3 protein-protein interactions in an FP assay with an IC50 of 2.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Blapsin B Related Antibodies
Molecular Weight

274.27

Formula

C15H14O5
CAS No.
SMILES

OC1=CC=C(C2OCCC3=CC(O)=C(C=C32)O)C=C1O
Structure Classification
Initial Source

from the insect Blaps japanensis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Blapsin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blapsin B861145-00-8Drug DerivativeDrug derivative14-3-3ζ14-3-3-mediated signaling pathwaysapoptosiscell cycle arrest14-3-3 protein-protein interactionhuman cancersInhibitorinhibitorinhibit

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