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Isoforms Recommended:	5-HT₁ Receptor

Results for "

5HT1B?receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (18)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Neurological Disease (15)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CP 93129 dihydrochloride	5-HT Receptor	Neurological Disease
CP 93129 dihydrochloride is a potent *5HT_1B receptor* agonist. CP 93129 dihydrochloride has the potential for parkinson's disease research .

SB-224289 hydrochloride 2 Publications Verification SB-224289A	5-HT Receptor	Neurological Disease
SB-224289 hydrochloride is a selective **5-HT1B receptor** antagonist, with anxiolytic effect.

HY-101105

SB-224289

5-HT Receptor Neurological Disease

SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect .
HY-101049

CGS 12066 dimaleate

CGS 12066 (dimaleate) dimaleate is a selective 5-HT_1B receptor agonist with an IC₅₀ of 51 nM .

AR-A 2 AR-A 000002	5-HT Receptor	Neurological Disease
AR-A 2 is a selective *5-HT_1B receptor* antagonist, with high affinity to guinea pig cortex *5HT_1B/1D* and recombinant guinea pig *5-HT_1B receptors* (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1D receptor (K_i, 5 nM), and shows an EC₅₀ of 4.5 nM for the guinea pig *5-HT_1B receptor*; AR-A 2 can be used in the research of depression and anxiety.

HY-19477

SB-616234-A

SB-616234-A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.

GR 55562 dihydrochloride	5-HT Receptor	Neurological Disease
GR 55562 (dihydrochloride) is a selective *5-HT_1B receptor* antagonist. GR 55562 can be used for the research of nerve disease .

GR 55562 hydrochloride	5-HT Receptor	Neurological Disease
GR 55562 hydrochloride is a selective *5-HT_1B receptor* antagonist. GR 55562 hydrochloride can be used for the research of nerve disease .

NAS-181 dimesylate 1 Publications Verification	5-HT Receptor	Neurological Disease
NAS181 is a potent and selective antagonist of rat 5-HT_1B receptor, with a K_i of 47 nM. NAS181 shows 13-fold selectivity for r5-HT_1B over bovine 5-HT_1B receptor (K_i=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT_1B autoreceptors .

Eltoprazine DU 28853	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine shows antiaggressive and anxiogenic effects .

Eltoprazine hydrochloride DU 28853 hydrochloride	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects .

Eltoprazine dihydrochloride DU 28853 dihydrochloride	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) dihydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine dihydrochloride shows antiaggressive and anxiogenic effects .

Carpindolol SDZ21009	5-HT Receptor	Neurological Disease
Carpindolol (SDZ21009) is a **5-HT1B receptor antagonist (pK_d of 8.53 and pK_B** of 8.0) and a 5-HT1D receptor agonist (pEC₅₀ of 5.91 and pK_d of 6.37) .

Alprenolol 5 Publications Verification (RS)-Alprenolol; dl-Alprenolol	5-HT Receptor	Cancer
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and *5-HT1B* receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

Alprenolol hydrochloride 5 Publications Verification (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride	5-HT Receptor	Cancer
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and *5-HT1B* receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

PNU-142633	5-HT Receptor	Neurological Disease
PNU-142633 is a high affinity, selective and orally active 5-HT_1D receptor agonist with K_is of 6 nM and > 18 000 nM for human 5-HT_1D receptor and human 5-HT_1B receptor, respectively. PNU-142633 has anti-migraine efficacy .

Isamoltane hemifumarate
Isamoltane hemifumarate is a selective antagonist of *5-HT_1B receptor, with an IC₅₀* of 39 nM for inhibits the binding of [ ¹²⁵I]ICYP to 5-HT_1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC₅₀ of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity .

Alprenolol hydrochloride (Standard) (RS)-Alprenolol hydrochloride (Standard); dl-Alprenolol hydrochloride (Standard)	5-HT Receptor	Cancer
Alprenolol (hydrochloride) (Standard) is the analytical standard of Alprenolol (hydrochloride). This product is intended for research and analytical applications. Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and *5-HT1B* receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

LY310762 1 Publications Verification	5-HT Receptor	Cardiovascular Disease Neurological Disease
LY310762 is a selective 5-HT_1D receptor antagonist (K_i=249 nM) with a weak affinity for *5-HT_1B* receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HTSumatriptan (HY-B0121B)-induced decrease in excitatory postsynaptic potential (EPSC) amplitude .

CP94253 hydrochloride	5-HT Receptor	Neurological Disease
CP94253 hydrochloride is a potent and selective agonist of *5-HT_1B receptor* (K_i= 2 nM in a radioligand binding assay).K_i values for 5-HT_1A, 5-HT_1D, 5-HT_1C and 5-HT₂ receptors are 89, 49, 860, and 1600 nM respectively . CP94253 hydrochloride is centrally active upon systemic administration in vivo .

SB-216641A SB-216641 hydrochloride	5-HT Receptor	Neurological Disease
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of **5-HT_1B/D receptor*. SB-216641A shows high affinity and selectivity for h5-HT_1B receptors* over h5-HT_1D receptors. SB-216641A inhibits the function of SKF-99101H .

GR127935 hydrochloride
GR127935 hydrochloride is a potent and orally active 5-HT1D and **5-HT1B receptor** antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research .

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