Eltoprazine dihydrochloride  (Synonyms: DU 28853 dihydrochloride)

Eltoprazine (DU 28853) dihydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine dihydrochloride shows antiaggressive and anxiogenic effects^[1][2].

Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

293.19

C₁₂H₁₈Cl₂N₂O₂

143485-51-2

N1(C2=C3OCCOC3=CC=C2)CCNCC1.Cl.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66.  [Content Brief]

  [2]. Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31.  [Content Brief]