2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GR 55562 dihydrochloride

GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease.

For research use only. We do not sell to patients.

GR 55562 dihydrochloride Chemical Structure

GR 55562 dihydrochloride Chemical Structure

CAS No. : 159533-25-2

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Based on 1 publication(s) in Google Scholar

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Description

GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease[1].

In Vivo

GR 55562 (0.1-10 μg/side) into accumbens subregions did not evoke cocaine-lever responding[1].
GR 55562 (0.1-10 μg/side) in the accumbens shell or core failed to modulate the discriminative stimulus effects of cocaine (5 mg/kg)[1].
GR 55562 (1 μg/side) significantly attenuated the enhancement of cocaine discrimination[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (280-300 g; n=50)[1].
Dosage: 0.1-10 μg/side
Administration: Injected intracranially; At a volume of 0.2 µl/side
Result: Did not evoke substitution for the drug with intra-accumbal shell infusion.
Did not significantly affect the discriminative stimulus effects produced by 5 mg/kg of cocaine.
GR 55562 (1 µg/side) attenuated the enhancement of cocaine discrimination evoked by a combination of intra-accumbal core CP 93129 (1 µg/side) and systemic cocaine (1.25 mg/ kg or 2.5 mg/kg).
Molecular Weight

448.39

Formula

C23H27Cl2N3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(C2=CC=NC=C2)C=C1)C3=CC=C(O)C(CCCN(C)C)=C3.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation
References
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GR 55562 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR 55562159533-25-2GR55562GR-555625-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorserotonin (5-HT)antagonist5-HT1B receptorInhibitorinhibitorinhibit

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GR 55562 dihydrochloride
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HY-101367A
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