GR127935 hydrochloride
Based on 1 Customer Validation
GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 148642-42-6
- Formula: C29H32ClN5O3
- Molecular Weight:534.05
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
|
5-HT1A Receptor |
5-HT1B Receptor |
5-HT1D Receptor |
5-HT2A Receptor |
5-HT2C Receptor |
5-HT1B Receptor 8.5 (pKi) |
5-HT1D Receptor 8.5 (pIC50) |
Chemical Information
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CAS No. 148642-42-6
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Appearance Solid
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Molecular Weight 534.05
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Formula C29H32ClN5O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 83.33 mg/mL (156.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. J W Clitherow, et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J Med Chem. 1994 Jul 22;37(15):2253-7. [Content Brief]
[2]. Mohammad Nasehi, et al. Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia. Pharmacol Biochem Behav. 2014 Oct;125:70-77. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8725 mL | 9.3624 mL | 18.7248 mL | 46.8121 mL |
| 5 mM | 0.3745 mL | 1.8725 mL | 3.7450 mL | 9.3624 mL | |
| 10 mM | 0.1872 mL | 0.9362 mL | 1.8725 mL | 4.6812 mL | |
| 15 mM | 0.1248 mL | 0.6242 mL | 1.2483 mL | 3.1208 mL | |
| 20 mM | 0.0936 mL | 0.4681 mL | 0.9362 mL | 2.3406 mL | |
| 25 mM | 0.0749 mL | 0.3745 mL | 0.7490 mL | 1.8725 mL | |
| 30 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.5604 mL | |
| 40 mM | 0.0468 mL | 0.2341 mL | 0.4681 mL | 1.1703 mL | |
| 50 mM | 0.0374 mL | 0.1872 mL | 0.3745 mL | 0.9362 mL | |
| 60 mM | 0.0312 mL | 0.1560 mL | 0.3121 mL | 0.7802 mL | |
| 80 mM | 0.0234 mL | 0.1170 mL | 0.2341 mL | 0.5852 mL | |
| 100 mM | 0.0187 mL | 0.0936 mL | 0.1872 mL | 0.4681 mL |
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