1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Alprenolol hydrochloride

Alprenolol hydrochloride  (Synonyms: (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride)

Cat. No.: HY-B1517A Purity: 99.78%
COA Handling Instructions

Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent.

For research use only. We do not sell to patients.

Alprenolol hydrochloride Chemical Structure

Alprenolol hydrochloride Chemical Structure

CAS No. : 13707-88-5

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Solution
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 87 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 79 In-stock
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100 mg USD 132 In-stock
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200 mg USD 211 In-stock
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500 mg USD 475 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Alprenolol hydrochloride:

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  • Biological Activity

  • Purity & Documentation

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Description

Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].

IC50 & Target

5-HT1A Receptor

 

In Vivo

Alprenolol (p.o., 50 mg/kg) hydrochloride causes a significant drop in blood pressure which averages 20 mm Hg (at 3-hr) and an increase in heart rate by 39 beats/min (at 3-hr) in conscious renal hypertensive dogs[1].
Alprenolol (i.p., 5 mg/kg) hydrochloride effectively blockes the anxiolytic effects of indorenate and ipsapirone but do not reduce the motor activity in adult male Swiss Webster mice[2].
Alprenolol (intravenous injection, 0.5 or 1.0 mg/kg) can decrease systolic pressure by a mean of 10 mm Hg, diastolic pressure by a mean of 10 mm Hg) hydrochloride and heart rate by 23 beats/min, as well as slightly reduce both myocardial and liver blood flows by mean of 17% and 15% respectively at a dose of 1.0 mg/kg in cats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

285.81

Formula

C15H24ClNO2

CAS No.
SMILES

OC(COC1=CC=CC=C1CC=C)CNC(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (349.88 mM; Need ultrasonic)

H2O : 50 mg/mL (174.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4988 mL 17.4941 mL 34.9883 mL
5 mM 0.6998 mL 3.4988 mL 6.9977 mL
10 mM 0.3499 mL 1.7494 mL 3.4988 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 11 mg/mL (38.49 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (7.28 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.28 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.28 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.78%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Alprenolol hydrochloride
Cat. No.:
HY-B1517A
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