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Cat. No.: HY-101105

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SB-224289

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

For research use only. We do not sell to patients.

CAS No.: 180083-23-2
Formula: C₃₂H₃₂N₄O₃
Molecular Weight:520.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

SB-224289 Chemical Structure

CAS No.: 180083-23-2

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect^[1].

IC₅₀ & Target

5-HT_1B Receptor

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 180083-23-2
Molecular Weight 520.62
Formula C₃₂H₃₂N₄O₃
SMILES

O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)N4CCC5=C4C=C6C(OCC67CCN(C)CC7)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

PNAS Nexus

A PITX2-HTR1B pathway regulates the asymmetric development of female gonads in chickens. [Abstract]

2023 Jun 19;2(6):pgad202. PMID: 37388922
Authorea

September 19, 2022.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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