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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
ALK4 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "ALK4 receptor" in MCE Product Catalog:
316
316 Publications Verification
Target:
Research Areas:
SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .
141
141 Cited Publications
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A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
141
141 Cited Publications
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Research Areas:
A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
24
24 Cited Publications
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SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
24
24 Cited Publications
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SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
13
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Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect .
13
13 Cited Publications
Cat. No.: HY-19928A
CAS No.: 1352610-25-3
Synonyms: EW-7197 Hydrochloride; TEW-7197 Hydrochloride
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Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect .
Cat. No.: HY-10431R
CAS No.: 301836-41-9
Research Areas:
SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .
Cat. No.: HY-117887
CAS No.: 2141955-96-4
Synonyms: BLU-782; IPN-60130; ALK2-IN-1
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Fidrisertib (BLU-782) is the orally active inhibitor for activin receptor-like kinase 2 (ALK2) that inhibits ALK2 R206H, ALK2, ALK1, ALK6, ALK3, ALK4, TGFβR2 and ALK5 with IC50s of 0.2, 0.6, 3, 24, 45, 65, 67 and 155 nM, respectively .
Cat. No.: HY-10432R
CAS No.: 909910-43-6
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A 83-01 (Standard) is the analytical standard of A 83-01 (HY-10432). This product is intended for research and analytical applications. A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
Cat. No.: HY-13521AR
CAS No.: 356559-13-2
Target:
Research Areas:
SB-505124 (hydrochloride) (Standard) is the analytical standard of SB-505124 (hydrochloride). This product is intended for research and analytical applications. SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
Cat. No.: HY-13521R
CAS No.: 694433-59-5
Target:
Research Areas:
SB-505124 (Standard) is the analytical standard of SB-505124. This product is intended for research and analytical applications. SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
Cat. No.: HY-P7485
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin receptor-Like Kinase 4; Prev. ACVRLK4; Activin receptor Type-1B; ALK4; Activin A receptor, Type II-Like Kinase 4; SKR2; Activin receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase receptor R2; ALK-4; Activin A receptor Type
Cat. No.: HY-P7486
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin receptor-Like Kinase 4; Prev. ACVRLK4; Activin receptor Type-1B; ALK4; Activin A receptor, Type II-Like Kinase 4; SKR2; Activin receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase receptor R2; ALK-4; Activin A receptor Type
Cat. No.: HY-P75571
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin receptor-Like Kinase 4; Prev. ACVRLK4; Activin receptor Type-1B; ALK4; Activin A receptor, Type II-Like Kinase 4; SKR2; Activin receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase receptor R2; ALK-4; Activin A receptor Type
Cat. No.: HY-P75572
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin receptor-Like Kinase 4; Prev. ACVRLK4; Activin receptor Type-1B; ALK4; Activin A receptor, Type II-Like Kinase 4; SKR2; Activin receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase receptor R2; ALK-4; Activin A receptor Type
Cat. No.: HY-P76718
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin receptor-Like Kinase 4; Prev. ACVRLK4; Activin receptor Type-1B; ALK4; Activin A receptor, Type II-Like Kinase 4; SKR2; Activin receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase receptor R2; ALK-4; Activin A receptor Type
Cat. No.: HY-P77294
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin receptor-Like Kinase 4; Prev. ACVRLK4; Activin receptor Type-1B; ALK4; Activin A receptor, Type II-Like Kinase 4; SKR2; Activin receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase receptor R2; ALK-4; Activin A receptor Type
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
