1. TGF-beta/Smad
  2. TGF-β Receptor

Vactosertib (Synonyms: EW-7197; TEW-7197)

Cat. No.: HY-19928 Purity: 99.58%
Handling Instructions

Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations.

For research use only. We do not sell to patients.

Vactosertib Chemical Structure

Vactosertib Chemical Structure

CAS No. : 1352608-82-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 114 In-stock
Estimated Time of Arrival: December 31
2 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Estimated Time of Arrival: December 31
50 mg USD 816 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of Vactosertib:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations.

IC50 & Target

IC50: 12.9 nM (TRPV4)[1]

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (208.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5036 mL 12.5182 mL 25.0363 mL
5 mM 0.5007 mL 2.5036 mL 5.0073 mL
10 mM 0.2504 mL 1.2518 mL 2.5036 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

399.42

Formula

C₂₂H₁₈FN₇

CAS No.

1352608-82-2

SMILES

CC1=CC=CC(C2=C(C3=CN4C(C=C3)=NC=N4)NC(CNC5=CC=CC=C5F)=N2)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.58%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Vactosertib
Cat. No.:
HY-19928
Quantity:

Vactosertib

Cat. No.: HY-19928