1. TGF-beta/Smad
  2. TGF-β Receptor

EW-7197 (Synonyms: Vactosertib)

Cat. No.: HY-19928 Purity: 99.12%
Handling Instructions

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively.

For research use only. We do not sell to patients.

EW-7197 Chemical Structure

EW-7197 Chemical Structure

CAS No. : 1352608-82-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 114 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
2 mg USD 90 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 130 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 816 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of EW-7197:

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  • Technical Information

  • Purity & Documentation

  • References

Description

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. target: ALK4/ALK5 IC 50: 13 nM for TGF-β receptor ALK4, 11 nM for TGF-β receptor ALK5. [1] In vitro: EW-7197 inhibits TGFβ-induced Smad2 or Smad3 phosphorylation and the epithelial-to-mesenchymal transition (EMT) in TGFβ-treated breast cancer cells. In addition, EW-7197 also abrogates TGFβ1-induced tumor cell migration and invasion in breast cells. EW-7197 inhibited Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in mouse mammary tumor virus. [2] In vivo: EW-7197 inhibition downregulates Smad4 in melanoma-bearing mice. EW-7197 induces ubiquitin-mediated degradation of Smad4 in melanoma-bearing mice. In a mouse B16 melanoma model, EW-7197 (2.5 mg/kg daily p.o.) suppresses the progression of melanoma with enhanced cytotoxic T-lymphocyte (CTL) responses. EW-7197 dissolved in artificial gastric fluid formulation (vehicle; ddH2O 900 ml, conc. HCl 7 ml, NaCl 2.0 g, pepsin 3.2 g) was given orally by feeding needle to mice from 4 days after inoculation. [3]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5036 mL 12.5182 mL 25.0363 mL
5 mM 0.5007 mL 2.5036 mL 5.0073 mL
10 mM 0.2504 mL 1.2518 mL 2.5036 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

399.42

Formula

C₂₂H₁₈FN₇

CAS No.

1352608-82-2

SMILES

CC1=CC=CC(C2=C(C3=CN4C(C=C3)=NC=N4)NC(CNC5=CC=CC=C5F)=N2)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.12%

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Product Name:
EW-7197
Cat. No.:
HY-19928
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EW-7197

Cat. No.: HY-19928