1. TGF-beta/Smad
  2. TGF-β Receptor

EW-7197 (Synonyms: Vactosertib)

Cat. No.: HY-19928 Purity: 99.12%
Handling Instructions

EW-7197 is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations.

For research use only. We do not sell to patients.

EW-7197 Chemical Structure

EW-7197 Chemical Structure

CAS No. : 1352608-82-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 114 In-stock
Estimated Time of Arrival: December 31
2 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Estimated Time of Arrival: December 31
50 mg USD 816 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of EW-7197:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

EW-7197 is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations.

IC50 & Target

IC50: 12.9 nM (TRPV4)[1]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (208.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5036 mL 12.5182 mL 25.0363 mL
5 mM 0.5007 mL 2.5036 mL 5.0073 mL
10 mM 0.2504 mL 1.2518 mL 2.5036 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

399.42

Formula

C₂₂H₁₈FN₇

CAS No.

1352608-82-2

SMILES

CC1=CC=CC(C2=C(C3=CN4C(C=C3)=NC=N4)NC(CNC5=CC=CC=C5F)=N2)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.12%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
EW-7197
Cat. No.:
HY-19928
Quantity:

EW-7197

Cat. No.: HY-19928