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A 83-01 sodium

148 Cited Publications
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Based on 148 publication(s) in Google Scholar

A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

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  • Pureté : 98.03%
  • CAS No.: 2828431-89-4
  • Formule: C25H19N5NaS
  • Masse moléculaire:444.51
  • Stockage:

    4°C, sealed storage, away from moisture and light

    * The compound is unstable in solutions, freshly prepared is recommended.

  • A 83-01 sodium Chemical Structure
    A 83-01 sodium Chemical Structure
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
CAS No.: 2828431-89-4
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  • A 83-01 sodium Chemical Structure
    A 83-01 sodium Chemical Structure
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    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 May 2;85(9):1628-1643. [Abstract]

    Customer Validation
     A83-01 (10 μM; 12 h) suppresses the expression of XYLT1 in bone-metastatic A549 cells.

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]

    Customer Validation
     Trophoblast organoids constructed from hTSCs-BL. Trophoblast markers: CDH1 and hCG. Briefly, hTSCs were cultured in hTSCs medium (DMEM/F12 supplemented with 0.1 mM 2-mercaptoethanol, 0.2% FBS, 0.5% Penicillin–Streptomycin, 0.3% BSA, 1% ITS-X supplement, 1.5 μg/ml L-ascorbicacid, 50 ng/mL Epidermal Growth Factor (EGF)(MedChemExpress), 2 μM CHIR99021 (MedChemExpress), 0.5 μM A83-01 (MedChemExpress), 1 μM SB431542 (MedChemExpress), 0.8 mM Valproic acid and 5 μM Y27632 (MedChemExpress).

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Genome Med. 2024 Apr 24;16(1):60. [Abstract]

    Customer Validation
     Cell viability assessment in the AtT20 cell line treated with Activin A (10 ng/ml) in the presence or absence of SB-505124 (1 μM), A 83–01 (1 μM; 24-96 h), or follistatin (100 ng/ml). K Cell viability analysis in AtT20 cell line with shEV-GFP or shAcvr1b treated with Activin A (10 ng/ml).

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Nat Protoc. 2023 May;18(5):1584-1620. [Abstract]

    Customer Validation
     hPSCs are dissociated into single cells (Steps 35-47) and plated in non-adherent hydrogel microwells or AggreWell plate to form small aggregates of the cells (steps 48-53). Upon exposure to lysophosphatidic acid (LPA), A83-01 and PD0325901 in a chemically defined medium containing leukaemia inhibitory factor (LIF) and Y-27632 for 2 days, some aggregates form small cavities (steps 54-61). With continuing culture for 2 days in a medium containing LPA and Y-27632, human blastoidss are formed efficiently and consistently (Steps 62-65). N2B27, serum-free medium; PALLY, PD0325901 + A83-01 + LPA + hLIF + Y-27632; LY, LPA + Y-27632.

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: FASEB J. 2020 Aug;34(8):11185-11199. [Abstract]

    Customer Validation
     Changes in the expression of E-Cadherin (green) and Vimentin (red) are detected by immunofluorescence. TGF-β1-induced changes in the expression of protein markers during EMT were blocked after A83-01 treatment.

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    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Gynecol Oncol. 2019 Jun;153(3):639-650. [Abstract]

    Customer Validation
     Analysis of E-cadherin, N-cadherin,MMP-2 and pSmad2 in SK-OV-3 and OVCAR-3 cells treated with platelets, A83-01 or their combination at protein levels (n=3). GAPDH is used as loading control.

  • A 83-01 sodium