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A 83-01 sodium

141 Cited Publications
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Based on 141 publication(s) in Google Scholar

A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

For research use only. We do not sell to patients.

  • Purity: 98.03%
  • CAS No.: 2828431-89-4
  • Formula: C25H19N5NaS
  • Molecular Weight:444.51
  • Storage:

    4°C, sealed storage, away from moisture and light

    * The compound is unstable in solutions, freshly prepared is recommended.

  • A 83-01 sodium Chemical Structure
    A 83-01 sodium Chemical Structure
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
  • Experimental Validation Results for A 83-01 sodium
CAS No.: 2828431-89-4
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IFWBRT-PCRCell Proliferation/Viability Assay
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  • A 83-01 sodium Chemical Structure
    A 83-01 sodium Chemical Structure
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    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 May 2;85(9):1628-1643. [Abstract]

    Customer Validation
     A83-01 (10 μM; 12 h) suppresses the expression of XYLT1 in bone-metastatic A549 cells.

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]

    Customer Validation
     Trophoblast organoids constructed from hTSCs-BL. Trophoblast markers: CDH1 and hCG. Briefly, hTSCs were cultured in hTSCs medium (DMEM/F12 supplemented with 0.1 mM 2-mercaptoethanol, 0.2% FBS, 0.5% Penicillin–Streptomycin, 0.3% BSA, 1% ITS-X supplement, 1.5 μg/ml L-ascorbicacid, 50 ng/mL Epidermal Growth Factor (EGF)(MedChemExpress), 2 μM CHIR99021 (MedChemExpress), 0.5 μM A83-01 (MedChemExpress), 1 μM SB431542 (MedChemExpress), 0.8 mM Valproic acid and 5 μM Y27632 (MedChemExpress).

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Genome Med. 2024 Apr 24;16(1):60. [Abstract]

    Customer Validation
     Cell viability assessment in the AtT20 cell line treated with Activin A (10 ng/ml) in the presence or absence of SB-505124 (1 μM), A 83–01 (1 μM; 24-96 h), or follistatin (100 ng/ml). K Cell viability analysis in AtT20 cell line with shEV-GFP or shAcvr1b treated with Activin A (10 ng/ml).

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: FASEB J. 2020 Aug;34(8):11185-11199. [Abstract]

    Customer Validation
     Changes in the expression of E-Cadherin (green) and Vimentin (red) are detected by immunofluorescence. TGF-β1-induced changes in the expression of protein markers during EMT were blocked after A83-01 treatment.

  • 1/16

    A 83-01 sodium purchased from MedChemExpress. Usage Cited in: Gynecol Oncol. 2019 Jun;153(3):639-650. [Abstract]

    Customer Validation
     Analysis of E-cadherin, N-cadherin,MMP-2 and pSmad2 in SK-OV-3 and OVCAR-3 cells treated with platelets, A83-01 or their combination at protein levels (n=3). GAPDH is used as loading control.

  • A 83-01 sodium