Adamts5

By Targets:	ADAMTS (11) AP-1 (3) Bacterial (1) Biochemical Assay Reagents (1) Isotope-Labeled Compounds (1) MMP (4) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: ADAMTS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12270

T-5224 Maximum Cited Publications 100 Publications Verification	AP-1 MMP	Neurological Disease Inflammation/Immunology Cancer
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-114996

ADAMTS-5 Inhibitor 4 Publications Verification	ADAMTS	Inflammation/Immunology
ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC₅₀ of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .

HY-137430

Aldumastat 1 Publications Verification GLPG1972; S201086	ADAMTS	Metabolic Disease
Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active *ADAMTS-5* (IC₅₀=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC₅₀=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .

HY-135710

ADAMTS-5-IN-2	ADAMTS Bacterial	Infection Inflammation/Immunology
ADAMTS-5-IN-2 is an inhibitor of *ADAMTS-5* (IC₅₀: 9.6 μM) and BoNT/A LC (IC₅₀: 0.71 μM). ADAMTS-5-IN-2 can be used in research related to botulism, osteoarthritis, and other conditions .

HY-145061

ADAMTS-5-IN-3	ADAMTS	Metabolic Disease Inflammation/Immunology
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of *ADAMTS-5* and *ADAMTS-4* with IC₅₀s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .

HY-160822

AGG-523 PF-5212371	ADAMTS MMP	Inflammation/Immunology
AGG-523 (PF-5212371) is an orally active, reversible, non-hydroxamate, zinc-binding selective inhibitor of *ADAMTS4* and *ADAMTS5* with IC₅₀of <0.03 and 0.04 μM. AGG-523 also inhibits MMP-2, -8, 12 activity AGG-523 attenuates release of aggrecanase-generated ARG-aggrecan fragments into synovial fluid, reduces surgery-induced ARG-aggrecan release in rat joint models, and inhibits aggrecanase activity to slow cartilage degradation. AGG-523 can be used for the research of osteoarthritis .

HY-P10398

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-RS00305

ADAMTS5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAMTS5 Human Pre-designed siRNA Set A ADAMTS5 Human Pre-designed siRNA Set A

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-RS18432

Adamts5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adamts5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adamts5 Mouse Pre-designed siRNA Set A Adamts5 Mouse Pre-designed siRNA Set A

HY-RS24913

Adamts5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adamts5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adamts5 Rat Pre-designed siRNA Set A Adamts5 Rat Pre-designed siRNA Set A

HY-12270R

T-5224 (Standard)	AP-1 MMP	Others
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-P10468

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-180781

ADAMTS-5-IN-4	ADAMTS	Inflammation/Immunology Cancer
ADAMTS-5-IN-4 (Compound 4b) is a selective *ADAMTS5* inhibitor with an IC₅₀ of 9.4 μM. ADAMTS-5-IN-4 significantly inhibits the degradation of Aggrecan in the implants of the osteoarthritis model. ADAMTS-5-IN-4 effectively inhibits the pseudopod elongation and directional migration of ovarian cancer cells. ADAMTS-5-IN-4 shows significant cytotoxicity to HEK293T cells, human chondrocytes, and porcine chondrocyte implants. ADAMTS-5-IN-4 can be used for the study of osteoarthritis and ovarian cancer .

HY-P992336

CRB0017	ADAMTS	Inflammation/Immunology
CRB0017 is a recombinant monoclonal antibody targeting *ADAMTS5, with high affinity for the spacer domain of ADAMTS5* and strong antigen specificity. CRB0017 binds to the spacer domain of *ADAMTS5* and reduces the proteolytic activity of this enzyme. CRB0017 delays articular cartilage degradation, alleviates the pathological severity of osteoarthritis, and decreases the osteoarthritis histopathological score. CRB0017 is applicable to the research of osteoarthritis .

HY-P992358

GSK2394002	ADAMTS	Cardiovascular Disease
GSK2394002 is an antibody inhibitor targeting *ADAMTS-4* and *ADAMTS-5*, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .

HY-153505

ADAMTS-4/5-IN-1	ADAMTS	Inflammation/Immunology
ADAMTS-4/5-IN-1 is an orally active, and selective dual *ADAMTS-4/5 inhibitor with IC₅₀* values of 2 nM for human *ADAMTS-4* and human *ADAMTS-5, respectively. ADAMTS-4/5-IN-1 exhibits high selectivity against MMP* enzymes. ADAMTS-4/5-IN-1 reduces aggrecan degradation products in synovial fluid. ADAMTS-4/5-IN-1 can be used for the research of osteoarthritis .

HY-12270S

T-5224-d8	Isotope-Labeled Compounds AP-1 MMP	Inflammation/Immunology
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Product Name	Target	Research Area

HY-P10398

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-P10468

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

HY-P5419

WAAG-3R	Peptides	Others
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

Cat. No.	Product Name	Target	Research Area	Image

HY-P992336

CRB0017	ADAMTS	Inflammation/Immunology
CRB0017 is a recombinant monoclonal antibody targeting *ADAMTS5, with high affinity for the spacer domain of ADAMTS5* and strong antigen specificity. CRB0017 binds to the spacer domain of *ADAMTS5* and reduces the proteolytic activity of this enzyme. CRB0017 delays articular cartilage degradation, alleviates the pathological severity of osteoarthritis, and decreases the osteoarthritis histopathological score. CRB0017 is applicable to the research of osteoarthritis .

HY-P992358

GSK2394002	ADAMTS	Cardiovascular Disease
GSK2394002 is an antibody inhibitor targeting *ADAMTS-4* and *ADAMTS-5*, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .

Cat. No.	Product Name	Chemical Structure

HY-12270S

T-5224-d8
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81193

	ADAMTS5 Antibody (YA3480) 1 Publications Verification A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5; A Disintigrin And Metalloproteinase with ThromboSpondin motif-5; ADAM metallopeptidase with thrombospondin type 1 motif 5; ADAM TS 11; ADAM TS 5; ADAM TS5; Adamts 11; Adamts 5; Adamts11; ADMP 2; ADMP2; Aggrecanase 2; aggrecanase-2; FLJ36738; Implantin; ThromboSpondin motif-5.	WB, ICC/IF, FC	Human, Mouse, Rat
	ADAMTS5 Antibody (YA3480) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAMTS5.

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Cat. No.	Product Name		Classification

HY-RS00305

ADAMTS5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18432

Adamts5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Adamts5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24913

Adamts5 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Adamts5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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