2. Metabolic Enzyme/Protease
  3. ADAMTS
  4. ADAMTS-5-IN-4

ADAMTS-5-IN-4 (Compound 4b) is a selective ADAMTS5 inhibitor with an IC₅₀ of 9.4 μM. ADAMTS-5-IN-4 significantly inhibits the degradation of Aggrecan in the implants of the osteoarthritis model. ADAMTS-5-IN-4 effectively inhibits the pseudopod elongation and directional migration of ovarian cancer cells. ADAMTS-5-IN-4 shows significant cytotoxicity to HEK293T cells, human chondrocytes, and porcine chondrocyte implants. ADAMTS-5-IN-4 can be used for the study of osteoarthritis and ovarian cancer.

For research use only. We do not sell to patients.

ADAMTS-5-IN-4

ADAMTS-5-IN-4 Chemical Structure

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ADAMTS-5-IN-4 Related Antibodies

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Description

ADAMTS-5-IN-4 (Compound 4b) is a selective ADAMTS5 inhibitor with an IC₅₀ of 9.4 μM. ADAMTS-5-IN-4 significantly inhibits the degradation of Aggrecan in the implants of the osteoarthritis model. ADAMTS-5-IN-4 effectively inhibits the pseudopod elongation and directional migration of ovarian cancer cells. ADAMTS-5-IN-4 shows significant cytotoxicity to HEK293T cells, human chondrocytes, and porcine chondrocyte implants. ADAMTS-5-IN-4 can be used for the study of osteoarthritis and ovarian cancer[1].

Molecular Weight

631.74

Formula

C30H41N5O8S
SMILES

CCC(N(S(=O)(C1=CC=C(C=C1)C2=CC=CC=C2)=O)CC3=CN(N=N3)CCCO[C@H]4[C@H](NC(C)=O)C(O)[C@H](O)[C@@H](CO)O4)C
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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ADAMTS-5-IN-4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADAMTS-5-IN-4ADAMTSAdamalysin-like metalloproteinase with thrombospondin motifsADAMTS5AggrecanVersicanGlycoconjugatesOsteoarthritisOvarian cancerInhibitorinhibitorinhibit

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