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Results for "

Akt1+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

12

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天然物

製品番号 製品名 Target 研究分野 構造式
  • HY-176299
    Tanerasertib

    		Akt Cancer
    Tanerasertib (Compound 456) is an AKT1 inhibitor, targerting to AKT1 E17K with the EC50 of 15-60 nM. Tanerasertib can be used in the study of cancer [1].
    Tanerasertib
  • HY-13254A
    A-674563 hydrochloride
    5 Publications Verification

    		 Akt Cancer
    A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
    A-674563 hydrochloride
  • HY-13254
    A-674563
    5 Publications Verification

    		 Akt Cancer
    A-674563 is an orally active Akt1 inhibitor with a Ki of 11 nM.
    A-674563
  • HY-N8122
    24-Methylenecycloartanyl ferulate

    		Akt Cancer
    24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM) [1].
    24-Methylenecycloartanyl ferulate
  • HY-163579
    Akt1-IN-7

    		Akt Cancer
    Akt1-IN-7 (Compound 370) is an Akt1 inhibitor (IC50: <15 nM) [1].
    Akt1-IN-7
  • HY-16461
    Solenopsin

    (-)-Solenopsin A

    		 Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cardiovascular Disease
    Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC50 of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases [1] .
    Solenopsin
  • HY-146459
    Akt1-IN-1
    1 Publications Verification

    		 Akt Cancer
    Akt1-IN-1 (compound 5b) is a potent and selective Akt1 inhibitor with an IC50 value of 18.79 nM in MIA Paca-2 cells. Akt1-IN-1 does not exhibit obvious teratogenicity, hepatotoxicity and cardiotoxicity (No Observed Adverse Effect Level > 100 µM). Akt1-IN-1 can be used for researching anticancer [1].
    Akt1-IN-1
  • HY-175716
    AKT1-IN-10

    		Akt Cancer
    AKT1-IN-10 (Compound I-118) is a non-covalent allosteric AKT1 inhibitor with an IC50 of < 500 μM. AKT1-IN-10 has oral bioavailability.AKT1-IN-10 can be used in cancer [1].
    AKT1-IN-10
  • HY-163577
    Akt1-IN-5

    		Akt Cancer
    Akt1-IN-5 (Compound 115) is an Akt1 inhibitor (IC50: <15 nM) [1]
    Akt1-IN-5
  • HY-163578
    Akt1-IN-6

    		Akt Cancer
    Akt1-IN-6 (Compound 273) is an Akt1 inhibitor (IC50: <15 nM) [1]
    Akt1-IN-6
  • HY-123390
    DB07107

    		Bcr-Abl Akt Cancer
    DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM [1] .
    DB07107
  • HY-183124
    AKT1-IN-12

    		Akt Cancer
    AKT1-IN-12 is a AKT1 inhibitor. AKT1-IN-12 is applicable to research related to breast cancer, colorectal cancer and meningioma [1].
    AKT1-IN-12

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