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5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways .
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2(Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .
Zansecimab (LY-3127804) is an immunoglobulin G4-kappa, a monoclonal antibody against angiopoietin 2(Ang 2). Zansecimab has potential applications in angiogenesis and immune regulation [2] .
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2(Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2(Ang2) with high affinity, but shows no binding to Ang1 .
Zansecimab (LY-3127804) is an immunoglobulin G4-kappa, a monoclonal antibody against angiopoietin 2(Ang 2). Zansecimab has potential applications in angiogenesis and immune regulation [2] .
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways .
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulating ANGPT1 signaling and inducing TEK/TIE2 phosphorylation even without ANGPT1. In the absence of angiogenic stimuli, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vascular regression. However, in the presence of VEGF, ANGPT2 collaborates to promote endothelial cell migration and proliferation, serving as a permissive angiogenic signal. Additionally, ANGPT2 regulates lymphangiogenesis, interacting with TEK/TIE2 and ITGA5, highlighting its diverse roles in angiogenesis and vascular control. Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is 222 a.a., with molecular weight of 32-37 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of Angiopoietin-2 Protein, Human (HEK293, His-Avi) is 222 a.a., with molecular weight of 30-40 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His) is 222 a.a., with molecular weight of 30-40 kDa.
Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) is 495 a.a., with molecular weight of ~56.2 KDa.
Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (222a.a, HEK293, His) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (222a.a, HEK293, His) is 222 a.a., with molecular weight of ~27.7 KDa.
Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 222 a.a., with molecular weight of ~53.8 KDa.
ANGPT2/Angiopoietin-2 (dog) complexly regulates angiogenesis by binding to TEK/TIE2, competitively affecting ANGPT1 signaling. It independently induces TEK/TIE2 phosphorylation and, in the absence of VEGF, may cause endothelial cell apoptosis, thereby promoting vascular regression. Angiopoietin-2 Protein, Canine (HEK293, His) is the recombinant canine-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-2 Protein, Canine (HEK293, His) is 222 a.a., with molecular weight of ~27.8 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, His) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Angiopoietin-2 Protein, Human (HEK293, His) is 478 a.a., with molecular weight of ~63.5 kDa.
Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-2 Protein, Mouse (HEK293, His) is 222 a.a., with molecular weight of ~33.4 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, Fc) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Human (HEK293, Fc) is 478 a.a., with molecular weight of 110-115 kDa.
ANGPT2 is a secreted factor on the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway and is involved in tumor angiogenesis. In the presence of ANGPT1, ANGPT2 antagonizes ANGPT1-mediated Tie2 phosphorylation, leading to vessel sprouting or degeneration depending on the level of VEGF-A. Overexpression or inhibition of ANGPT2 increases or decreases angiogenic capacity, respectively. Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) is 477 a.a., with molecular weight of 90-120 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (CHO, His) is the recombinant human-derived Angiopoietin-2 protein, expressed by CHO , with C-6*His labeled tag. The total length of Angiopoietin-2 Protein, Human (CHO, His) is 478 a.a., with molecular weight of ~62.6 kDa.
Angiopoietin-2 Protein, Human (222a.a, HEK293, His) is a circulating antagonistic ligand of the endothelial-specific Tie2 receptor and has been identified as an important gatekeeper of endothelial activation.
ANGPT2/Angiopoietin-2, Dog, intricately modulates angiogenesis by binding to TEK/TIE2, competitively impacting ANGPT1 signaling. It induces TEK/TIE2 phosphorylation independently and, in the absence of VEGF, may lead to endothelial apoptosis, contributing to vascular regression. Collaborating with VEGF, ANGPT2 facilitates angiogenesis, promoting endothelial cell migration and proliferation. Additionally, ANGPT2 regulates lymphangiogenesis, emphasizing its comprehensive role in vascular dynamics within dog biology. Its interactions with TEK/TIE2 and ITGA5 highlight its multifaceted contribution to angiogenesis and vascular regulation. ANGPT2/Angiopoietin-2, Dog (HEK293, His) is the recombinant dog-derived ANGPT2/Angiopoietin-2, Dog, expressed by HEK293, with C-6*His labeled tag. The total length of ANGPT2/Angiopoietin-2, Dog (HEK293, His) is 477 a.a., with molecular weight of 57.2 kDa.
Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Mouse (HEK293, Fc) is 478 a.a., with molecular weight of 90-120 kDa.
