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Ba/F3-ETV6-TRKAWT、Ba/F3-ETV6-TRKBWT、Ba/F3-LMNA-TRKG595R、Ba/F3-LMNA-TRKAG667C

" in MedChemExpress (MCE) Product Catalog:

17

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6

オリゴヌクレオチド

製品番号 製品名 Target 研究分野 構造式
  • HY-P99047
    Simtuzumab

    AB 0024; GS 6624

    		 Monoamine Oxidase Cardiovascular Disease Inflammation/Immunology
    Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis .
    Simtuzumab
  • HY-159834
    Progerinin

    SLC-D011

    		 DNA/RNA Synthesis Others
    Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor. Progerinin selectively binds to the C-terminal region of progerin, disrupting its interaction with lamin A and promoting progerin degradation while sparing wild-type lamin A, B, and C. Progerinin ameliorates nuclear deformation, increases H3K9me3 levels, and reduces progerin expression in HGPS patient-derived fibroblasts. Progerinin extends lifespan in Lmna G609G/G609G mice and Lmna G609G/+ mice, improves body weight, hair morphology, cardiac function, and histological phenotypes. Progerinin can be used for the study of Hutchinson-Gilford progeria syndrome (HGPS) .
    Progerinin
  • HY-RS26094
    Etv6 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Etv6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Etv6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Etv6 Rat Pre-designed siRNA Set A
    Etv6 Rat Pre-designed siRNA Set A
  • HY-RS19598
    Etv6 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Etv6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Etv6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Etv6 Mouse Pre-designed siRNA Set A
    Etv6 Mouse Pre-designed siRNA Set A
  • HY-RS04569
    ETV6 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ETV6 Human Pre-designed siRNA Set A contains three designed siRNAs for ETV6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ETV6 Human Pre-designed siRNA Set A
    ETV6 Human Pre-designed siRNA Set A
  • HY-RS07714
    LMNA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LMNA Human Pre-designed siRNA Set A contains three designed siRNAs for LMNA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LMNA Human Pre-designed siRNA Set A
    LMNA Human Pre-designed siRNA Set A
  • HY-149965
    TRK-IN-23

    		Trk Receptor Apoptosis Cancer
    TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKA G595R, TRKA F589L, and TRKA G667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells .
    TRK-IN-23
  • HY-163366
    TRK-IN-28

    		Trk Receptor Cancer
    TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRK WT, TRK G595R and TRK G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA WT, Ba/F3-ETV6-TRKB WT, Ba/F3-LMNA-TRK G595R and Ba/F3-LMNA-TRKA G667C, respectively .
    TRK-IN-28
  • HY-155046
    FGFR4-IN-14

    		FGFR Cancer
    FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC50: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC50s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC) .
    FGFR4-IN-14
  • HY-146807
    Type II TRK inhibitor 1

    		Trk Receptor Cancer
    Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA G667C and ETV6-TRKC G696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Type II TRK inhibitor 1
  • HY-RS19910
    Lmna Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lmna Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lmna gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lmna Mouse Pre-designed siRNA Set A
    Lmna Mouse Pre-designed siRNA Set A
  • HY-126287
    JND4135

    		Trk Receptor Apoptosis Cancer
    JND4135 is a Type II TRK inhibitor with IC50 values of 2.79, 3.19, and 3.01 nM against TRKA, TRKB, TRKC, respectively. JND4135 can overcome resistance from TRK xDFG and other mutant forms in the BaF3 stable model, inhibiting phosphorylation of both WT and xDFG mutant TRKs, along with their downstream signaling molecules. JND4135 can induce G0/G1 phase arrest and apoptosis in BaF3–CD74-TRKA-G667C cells. JND4135 shows tumor growth inhibition activity in the BaF3-CD74-TRKA-G667C mouse xenograft model .
    JND4135
  • HY-151945
    TRK II-IN-1

    		Trk Receptor FLT3 VEGFR RET Cancer
    TRK II-IN-1 is a potent type II TRK inhibitor, with IC50s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKA G667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC50s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers .
    TRK II-IN-1
  • HY-174161
    Type II TRK inhibitor 3

    		Trk Receptor Cancer
    Type II TRK inhibitor 3 (Compound 18d) is a Type II TRK inhibitor with IC50 values of 0.82, 1.82, and 0.12 nM for TRKAWT/G595R/G667C, respectively. Type II TRK inhibitor 3 exhibits antitumor activity .
    Type II TRK inhibitor 3
  • HY-144451
    TRK-IN-12

    		Trk Receptor Cancer
    TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRK G595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line .
    TRK-IN-12
  • HY-RS26411
    Lmna Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lmna Rat Pre-designed siRNA Set A contains three designed siRNAs for Lmna gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lmna Rat Pre-designed siRNA Set A
    Lmna Rat Pre-designed siRNA Set A
  • HY-180172
    TRK-IN-33

    		Trk Receptor Apoptosis Cancer
    TRK-IN-33 is a TRK inhibitor. TRK-IN-33 exhibits excellent TRKA G667C degradation (DC50 = 24.69 nM; Dmax > 90%), while sparing the wild-type protein in virto. TRK-IN-33 shows antiproliferative activities against Ba/F3-LMNA-NTRK1 G667C cells with an IC50 value of 2.48 nM. TRK-IN-33 effectively inhibits tumor growth and enhances apoptosis in tumor tissues with no apparent toxicity in vivio. TRK-IN-33 can be used for NTRK fusion−positive cancers research .
    TRK-IN-33

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