TRK-IN-12
TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2823342-34-1
- 分子式: C18H19ClFN5O3S
- 分子量:439.89
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
0.08 μM
Compound: 9e
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Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1
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[PMID: 34628036] |
| BaF3 | IC50 |
0.646 μM
Compound: 9e
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Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant
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[PMID: 34628036] |
化学情報
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CAS 番号 2823342-34-1
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分子量 439.89
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分子式 C18H19ClFN5O3S
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SMILES
CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TRK-IN-12 関連分類
HY-144451 関連分類
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