2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. TRK-IN-28

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRKWT, TRKG595R and TRKG667C, respectively. TRK-IN-2 shows antiproliferative activity with IC50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKAWT, Ba/F3-ETV6-TRKBWT, Ba/F3-LMNA-TRKG595R and Ba/F3-LMNA-TRKAG667C, respectively.

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TRK-IN-28 Chemical Structure

TRK-IN-28 Chemical Structure

CAS No. : 2991504-43-7

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TRK-IN-28 Related Antibodies

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Description

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRKWT, TRKG595R and TRKG667C, respectively. TRK-IN-2 shows antiproliferative activity with IC50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKAWT, Ba/F3-ETV6-TRKBWT, Ba/F3-LMNA-TRKG595R and Ba/F3-LMNA-TRKAG667C, respectively[1].

Molecular Weight

485.53

Formula

C27H25F2N7
CAS No.
SMILES

FC1=CC(CC2=CC3=C(NN=C3NC4=C5C=CC(N6CCN(CC6)C)=CC5=NC=N4)C=C2)=CC(F)=C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
References
Cell Assay

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TRK-IN-28 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-IN-282991504-43-7Trk ReceptorTropomyosin related kinase receptorantiproliferativeBa/F3-ETV6-TRKAWT、Ba/F3-ETV6-TRKBWT、Ba/F3-LMNA-TRKG595R、Ba/F3-LMNA-TRKAG667CInhibitorinhibitorinhibit

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