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Cat. No.: HY-163366

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TRK-IN-28

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK^WT, TRK^G595R and TRK^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA^WT, Ba/F3-ETV6-TRKB^WT, Ba/F3-LMNA-TRK^G595R and Ba/F3-LMNA-TRKA^G667C, respectively.

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CAS No.: 2991504-43-7
Formule: C₂₇H₂₅F₂N₇
Masse moléculaire:485.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

TRK-IN-28 Chemical Structure

CAS No.: 2991504-43-7

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Activité biologique
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- Cellular Effect
Chemical Information
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Trk Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	205 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G595R mutant assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G595R mutant assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]
BaF3	IC₅₀	3.7 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKB wildtype assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKB wildtype assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]
BaF3	IC₅₀	48.3 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G667C mutant assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G667C mutant assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]
BaF3	IC₅₀	9.5 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKA wildtype assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKA wildtype assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]

Chemical Information

CAS No. 2991504-43-7
Masse moléculaire 485.53
Formule C₂₇H₂₅F₂N₇
SMILES

FC1=CC(CC2=CC3=C(NN=C3NC4=C5C=CC(N6CCN(CC6)C)=CC5=NC=N4)C=C2)=CC(F)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

Cell Assay

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Références

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TRK-IN-28

Voir tous les produits spécifiques à Isoform Trk Receptor